In mature lymphocytes, the Spatio-temporal regulation of Ca2+ modulates signaling pathways. They serve to control a variety of cellular responses, such as activation, differentiation, effector function, and cell death. Thus, targeting…
MYC proteins include MYC (also known as c-MYC), MYCL, and MYCN. They play critical roles in tumorigenesis and therapeutic resistance. MYC proteins are implicated in up to 70% of all human…
T cells recognize antigen peptides associated with MHC (pMHC) through T cell antigen receptors (TCR). They comprise a complex of two antigen recognition subunits (TCRα/β) along with four signaling subunits…
The TRAF protein family comprises seven E3 ligase members, including TRAF6. Distinct receptor signaling pathways have different members, such as the IL-1 receptor family, T-cell receptor (TCR), IL-17 receptor, TNF…
In the previous blog, I have introduced C-176 as a strong and covalent mouse STING inhibitor. Today, I’d like to introduce another STINF inhibitor C-178 in the same article. STING,…