![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/03/BAY-1316957-is-a-Selective-and-Orally-Active-EP4-R-Antagonist-2021-03-23.jpg)
Prostaglandin E2 (PGE2) receptors (EP4-R) are a particularly promising anti-inflammatory and antinociceptive target. Prostaglandin E2 (PGE2) is responsible for inflammatory…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/02/Enpatoran-is-an-Orally-Active-and-Dual-TLR7-8-Inhibitor-2021-02-27.jpg)
Toll-like receptors 7 and 8 (TLR7/8) are receptors for single-stranded RNA that reside in the endosome. TLR8 mainly expresses in…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/02/GSK-J4-is-a-Dual-Inhibitor-of-H3K27me3-me2-Demethylases-JMJD3-KDM6B-and-UTX-KDM6A-2021-02-18.jpg)
H3K27me3 is an epigenetic modification of DNA packaging protein histone H3. Specifically, it is a marker for the trimethylation of…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/02/BMS-986202-is-an-Orally-Active-Tyk2-Inhibitor-that-Binds-to-Tyk2-JH2-2021-02-06.jpg)
Tyrosine kinase 2 (Tyk2) is a non-receptor tyrosine kinase belonging to the Janus kinase (JAK) family. Specifically, the mammalian JAK…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/11/MSC2360844-is-an-Orally-Active-and-Selective-PI3Kδ-Inhibitor-2020-11-07-1.jpg)
SLE is a complex autoimmune inflammatory disease that affects multiple organs with unpredictable flares. Autoantibody/antigen immune-complexes in turn can activate…