Autoimmune diseases, including rheumatoid arthritis (RA) and immune thrombocytopenia (ITP), are caused by aberrant immune responses. ITP is an autoimmune bleeding disorder in which opsonization by platelet-specific autoantibodies results in…
RORγt is a transcription factor of the RAR-related orphan nuclear receptor (ROR) family. It often expresses in Th17 cells and plays an important role in TH17 cell differentiation. RORγt can…
Th17 cells are third subset of CD4+ T effector cells in organ-specific autoimmunity. Th17 cells not only differ from Th1 and Th2 cells by the cytokines they produce but also…
Biologic agents are highly effective therapies. It greatly improves the standard of care for patients with rheumatoid arthritis (RA). Even with the significant improvement in care, the maximal benefit has…
Citrullination of arginine residues, catalyzed by five closely-related protein arginine deiminases (PADs 1-4 and PAD6), affects numerous physiological and pathological processes. Multiple tumors over-express PAD4, and it affects p53 function…