The angiotensin II receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. Angiotensin II receptors include four subtypes: AT1, AT2, AT3 and AT4. They are…
B-cell-activating factor (BAFF) is a member of the tumour-necrosis factor (TNF) family. BAFF is a trimeric membrane-bound or soluble factor. BAFF binds to three receptors: BCMA (B-cell maturation antigen), TACI…
CD6, a surface glycoprotein of T cells, is a rheostat-type signalosome that tunes T cell activation. It belongs to the superfamily of scavenger receptor cysteine-rich (SRCR) glycoproteins. CD6 has determinant…
Lupus, technically known as systemic lupus erythematosus (SLE), is an autoimmune disease, characterized by polyclonal B-cell proliferation and a variety of autoantibodies. Common symptoms include painful and swollen joints, fever,…
Complement component 3 is a protein of the immune system that contains 13 structural domains. C3 plays an important role in the complement system, and also promotes innate immunity. In humans,…
Interferons (IFNs) are a kind of cytokines, which is used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. There are three…
REV-ERB is a member of the nuclear receptor superfamily consisting of two similar proteins: REV-ERBα and REV-ERBβ. Like other NRs, REV-ERBs can be regulated by ligands, including naturally occurring heme.…
Mitochondria fusion and division can produce the majority of energy to sustain cellular activity. Mitochondria is a highly dynamic organelle. It can undergo the physiological process of fusion and fission.…
Atopic dermatitis is a chronically relapsing inflammatory skin disease. The characteristics of atopic dermatitis are eczema and even pruritus. The mechanism of itching evoked in atopic dermatitis is still not…
ARC 239 is a selective α2B/2C adrenoceptor antagonist. Besides, ARC 239 binds to CHO cell membranes expressing human recombinant α2A-, α2B- or α2C-adrenoceptor subtypes. α2 adrenoceptor is a G protein-coupled…