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Immune System Research

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Sparsentan (RE-021) is a Potent Dual Angiotensin II and Endothelin A Receptor Antagonist

Edward Jenner 2023-02-27

The angiotensin II receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. Angiotensin II receptors include four subtypes: AT1, AT2, AT3 and AT4. They are…

Autoimmune Disorders Inflammation Psoriasis

Tibulizumab (LY 3090106) is a Tetravalent Bispecific mAb Targeting BAFF and IL-17A

Edward Jenner 2023-01-31

B-cell-activating factor (BAFF) is a member of the tumour-necrosis factor (TNF) family. BAFF is a trimeric membrane-bound or soluble factor. BAFF binds to three receptors: BCMA (B-cell maturation antigen), TACI…

Arthritis Autoimmune Disorders Infection Psoriasis

Itolizumab is a Humanized Recombinant Anti-CD6 Monoclonal Antibody

Edward Jenner 2022-12-19

CD6, a surface glycoprotein of T cells, is a rheostat-type signalosome that tunes T cell activation. It belongs to the superfamily of scavenger receptor cysteine-rich (SRCR) glycoproteins. CD6 has determinant…

Autoimmune Disorders Systemic Lupus Erythematosus

Abetimus is an Immunosuppressant, can be Used to Research Systemic Lupus Erythematosus

Edward Jenner 2022-12-13

Lupus, technically known as systemic lupus erythematosus (SLE), is an autoimmune disease, characterized by polyclonal B-cell proliferation and a variety of autoantibodies.  Common symptoms include painful and swollen joints, fever,…

Autoimmune Encephalomyelitis Complement System

Pegcetacoplan is a Pegylated Complement C3 Inhibitor Peptide

Edward Jenner 2022-11-19

Complement component 3 is a protein of the immune system that contains 13 structural domains. C3 plays an important role in the complement system, and also promotes innate immunity. In humans,…

Inflammation Systemic Lupus Erythematosus

Sifalimumab (MEDI-545) is an Anti-IFNα Monoclonal Antibody

Edward Jenner 2022-10-25

Interferons (IFNs) are a kind of cytokines, which is used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. There are three…

Autoimmune Disorders Colitis Encephalomyelitis Inflammation

SR12418 is a REV-ERB-specific Synthetic Ligand

Edward Jenner 2022-10-15

REV-ERB is a member of the nuclear receptor superfamily consisting of two similar proteins: REV-ERBα and REV-ERBβ. Like other NRs, REV-ERBs can be regulated by ligands, including naturally occurring heme.…

Autoimmune Encephalomyelitis Inflammation Metabolic Disease Multiple Sclerosis Type 2 Diabetes Mellitus

MASM7 is a Mitofusin Activator and Can Achieve Mitochondrial Fusion

Edward Jenner 2022-09-01

Mitochondria fusion and division can produce the majority of energy to sustain cellular activity. Mitochondria is a highly dynamic organelle. It can undergo the physiological process of fusion and fission.…

Atopic Dermatitis Autoimmune Disorders

Bepotastine is a Selective and Orally Active Second-generation Histamine H1 receptor Antagonist

Edward Jenner 2022-08-09

Atopic dermatitis is a chronically relapsing inflammatory skin disease. The characteristics of atopic dermatitis are eczema and even pruritus. The mechanism of itching evoked in atopic dermatitis is still not…

Autoimmune Encephalomyelitis Inflammation

ARC 239 is a Selective α2B/2C Adrenoceptor Antagonist

Edward Jenner 2022-07-21

ARC 239 is a selective α2B/2C adrenoceptor antagonist. Besides, ARC 239 binds to CHO cell membranes expressing human recombinant α2A-, α2B- or α2C-adrenoceptor subtypes. α2 adrenoceptor is a G protein-coupled…

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You Missed

Pulmonary Arterial Hypertension (PAH)

PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH

Cancer Immune Metabolic Disease

Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research

Uncategorized

Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research

NASH obesity

Elafibranor is a PPARα/δ Agonist for Metabolic Disease Research

Immune System Research

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