![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/07/Berotralstat-BCX7353-is-a-Highly-Specific-and-Orally-Active-Plasma-Kallikrein-Inhibitor-2021-07-28.jpg)
Kallikrein (KLK) is a main rate-limiting enzyme of the kinin system. Specifically, Kallikrein cleaves the substrate peptide at the carbon…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/07/BMS-604992-EX-1314-is-a-Selective-and-Orally-Active-GHSR-Agonist-2021-07-24.jpg)
Neuroendocrine systems function to coordinate complex physiological and homeostatic processes, and the peptide hormone ghrelin is a key factor in…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/05/ACH-000143-is-an-Orally-Active-Melatonin-Receptor-Agonist-2021-05-17.jpg)
The melatonin receptor is a G protein-coupled receptor (GPCR) that binds to melatonin. Specifically, receptors are crucial in the signal cascade…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/04/GKA50-is-a-Potent-Glucokinase-Activator-2021-05-06.jpg)
Glucokinase (GK) is the rate-limiting enzyme of hepatic glucose metabolism and acts as a sensor for glucose-stimulated insulin release in β-cells.…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/04/CP-100356-is-an-Orally-Active-Dual-MDR1-BCRP-Inhibitor-2021-05-01-1.jpg)
During the drug discovery development, most new chemical entities (NCEs) suffer from limiting oral absorption after an oral administration. Besides…