![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/08/NX-13-Targets-and-Activates-NLRX1-to-Induce-Immunometabolic-Changes-2021-08-06.jpg)
NLRX1 is a highly conserved nucleotide-binding domain (NBD) and a member of the leucine-rich repeat (LRR) family (NLR). Specifically, NLRX1…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/02/BMS-986202-is-an-Orally-Active-Tyk2-Inhibitor-that-Binds-to-Tyk2-JH2-2021-02-06.jpg)
Tyrosine kinase 2 (Tyk2) is a non-receptor tyrosine kinase belonging to the Janus kinase (JAK) family. Specifically, the mammalian JAK…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/09/Plecanatide-is-an-Orally-Active-Guanylate-Cyclase-C-GC-C-Receptor-Agonist-2020-09-25.jpg)
Guanylyl cyclase-C (GC-C) is a transmembrane receptor for bacterial heat-stable enterotoxin and the mammalian peptides guanylin and uroguanylin. Guanylyl cyclase-C…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/01/ZK216348-is-a-Nonsteroidal-Selective-Glucocorticoid-Receptor-Agonist-2020-01-05.jpg)
Glucocorticoids (GCs) are the most commonly used anti-inflammatory and immunosuppressive drugs. GCs possess outstanding therapeutic effects, however, severe and sometimes…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/11/BRD5529-is-a-Selective-CARD9–TRIM62-PPI-Inhibitor-2019-11-18.jpg)
The allele family CARD9 variant relates to increased or protected risk of inflammatory bowel disease (IBD). Moreover, the susceptible variant…