Type 2 diabetes (T2D) is a chronic health condition that has reached alarming rates across the globe. The International Diabetes Federation (IDF) published the Diabetes Atlas, which estimated that 463…
Thyroid hormone receptor beta (THR-β), also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2). Besides, it is a nuclear receptor protein that is encoded by the THRB…
The SLC13 family comprises five family members. co-transports, NaS1 and NaS2. Sodium-coupled citrate transporter (NaCT) and NaDC1 and NaDC3 are responsible for transporting cellular anionic intermediates. For example, citrate can…
Fibroblast growth factor 21 (FGF21) is a protein that in mammals is encoded by the FGF21 gene. FGF21 is a stress-inducible hormone that has important roles in regulating energy balance…
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Meanwhile,…
Fasiglifam (TAK-875) acts as a novel, orally available, selective GPR40 agonist. TAK-875 (0.01-10 μM) produces a concentration-dependent increase in intracellular IP production in CHO-hGPR40, with EC50 of 0.072 μM. Fasiglifam…
In general, obesity more greatly contributes to the global burden of disease (also associated with co-morbidities) in recent years . For instance, there are type 2 diabetes mellitus (T2DM), hypertension,…
Galactosemia is a rare genetic metabolic disorder that affects an individual's ability to metabolize the sugar galactose properly. And it is mainly caused by deficient galactose-1 phosphate uridylyltransferase (GALT). As…
Dynamins are large superfamily GTPase proteins that are involved in various cellular processes including budding of transport vesicles, division of organelles, cytokinesis, and pathogen resistance. Dynamins contain five domains, including…
HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the…