Arginine vasopressin (AVP) has three receptor subtypes: V1a, V1b, and V2 receptors. Specifically, the action of vasopressin is mediated by stimulating tissue-specific G protein-coupled receptor (GPCR). Besides, Gq/11 and V2…
Aleglitazar (R1439) is a potent dual PPARα/γ agonist. And the IC50s are 38 nM and 19 nM for human PPARa and PPARγ, respectively. Furthermore, Aleglitazar can be used for the…
Cannabinoid receptor type 2 (CB2) is a G protein-coupled receptor of the cannabinoid receptor family. Specifically, the endogenous cannabinoid system consists of CB1 and CB2. Their endogenous ligands is relevant…
Bombesin is a 14-amino acid peptide. The bombesin (Bn) receptor family includes the gastrin-releasing peptide (GRPR) and neuromedin B (NMBR) receptors, Bn receptor subtype 3 (BRS-3) and Bn receptor subtype…
GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA). There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion…
Cyclooxygenase (COX) is a key step in the conversion of arachidonic acid to PGH2. Specifically, PGH2 is a direct substrate for a series of cell-specific prostaglandin and thromboxane syntheses. Besides,…
Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME). Cell surface receptors and their ligands can be internalized by some mechanistically distinct endocytic pathways. Those signal pathways include…
Cannabinoids are the main biologically active constituents of marijuana and cannabis derivatives. They have psychoactive effects. There are at least three CB receptors in human tissues: (i) CB1 receptors, (ii)…
Sulprostone (SHB 286), a potent PGE2 analogue, is one of the first EP3 selective agonists. While the half-life of PGE2 in vivo is extremely short, sulprostone (SHB 286) demonstrates an…