Interleukins are a group of cytokines (secreted proteins and signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). The majority of interleukins are synthesized by…
Psoriatic arthritis (PsA) is a complex and heterogeneous inflammatory disease that affects 20% to 30% of patients. Pro-inflammatory cytokines are the potential targets in inflammatory diseases. They have led to…
Aryl Hydrocarbon Receptor (AhR or AHR) is a cytoplasmic receptor and transcription factor that belongs to the family of basic helix-loop-helix transcription factors. The AhR is activated or inhibited by…
B-cell-activating factor (BAFF) is a member of the tumour-necrosis factor (TNF) family. BAFF is a trimeric membrane-bound or soluble factor. BAFF binds to three receptors: BCMA (B-cell maturation antigen), TACI…
CD6, a surface glycoprotein of T cells, is a rheostat-type signalosome that tunes T cell activation. It belongs to the superfamily of scavenger receptor cysteine-rich (SRCR) glycoproteins. CD6 has determinant…
The therapeutic potential of extra terminal domain inhibitor (iBET) has increasing studies both in oncology and immunoinflammatory. Moreover, iBETs are actively progressing in the clinic for oncology indications. Nevertheless, there…