Remibrutinib is an Orally Active BTK Inhibitor for Chronic Urticaria Research
Remibrutinib is a potent and orally active BTK inhibitor for Chronic urticaria (CU) research.
Ondansetron is a 5-HT3 Receptor Antagonist for Anti-inflammation Research
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory…
Vamorolone is a Steroidal Anti-inflammatory Agent for Duchenne Muscular Dystrophy Research
Duchenne muscular dystrophy (DMD) is a genetic muscle disease. And The feature is contraction-induced myofibre injury and inflammation. Besides, researchers found that NF-κB signaling is active in dystrophin deficient muscle.…
Chloroquine is an Autophagy and TLRs Inhibitor for Malaria and Rheumatoid Arthritis Research
Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Intersetingly, Chloroquine not only a excellent anti-inflammatory agent, but also demonstrates more activities about cancer,…
Dexamethasone is a Glucocorticoid Receptor Agonist for Inflammation
Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body…
BQ-3020 is a Selective ETB Receptor Agonist for Cardiovascular Disease Research
ETA and ETB Receptor are isoforms of endothelin receptor. The ETA receptors on vascular smooth muscle cells mediate vasoconstriction. Otherwise, ETB Receptor is present in both endothelial and vascular smooth…
I-287 is an Orally Active PAR2 Inhibitor for Inflammation Research
Effect of I-287 on intracellular signaling pathways induced by the two human PAR2 agonists, Trypsin, and SLIGKV-NH2.
Tofacitinib is an JAK3/2/1 Inhibitor for Chronic Inflammatory Disorders Research
JAK is a family of cytoplasmic tyrosine kinases consisting of four isoforms, JAK1, JAK2, JAK3 and TYK2. According to studies, JAKs transduce cytokine-mediated signals through the family of signal transducers…
ARN14494 is a Selective Serine Palmitoyltransferase (SPT) Inhibitor and Can be Used for Alzheimer’s Disease Research
Serine palmitoyltransferase (SPT) is a key enzyme of sphingolipid metabolism. And it belongs to a family of pyridoxal 5'-phosphate-dependent alpha-oxoamine synthases. Sphingolipids are one of the major membrane lipids in…
SX 011 is an Orally Active p38 Inhibitor for Inflammation Research
The p38 MAPK pathway is a key regulatory factor for the biosynthesis of pro-inflammatory cytokines at the transcription and translation levels. There are four splicing variants in the p38 family:…