Remibrutinib is an Orally Active BTK Inhibitor for Chronic Urticaria Research
Remibrutinib is a potent and orally active BTK inhibitor for Chronic urticaria (CU) research.
Remibrutinib is a potent and orally active BTK inhibitor for Chronic urticaria (CU) research.
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory…
Duchenne muscular dystrophy (DMD) is a genetic muscle disease. And The feature is contraction-induced myofibre injury and inflammation. Besides, researchers found that NF-κB signaling is active in dystrophin deficient muscle.…
Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Intersetingly, Chloroquine not only a excellent anti-inflammatory agent, but also demonstrates more activities about cancer,…
Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body…
ETA and ETB Receptor are isoforms of endothelin receptor. The ETA receptors on vascular smooth muscle cells mediate vasoconstriction. Otherwise, ETB Receptor is present in both endothelial and vascular smooth…
Effect of I-287 on intracellular signaling pathways induced by the two human PAR2 agonists, Trypsin, and SLIGKV-NH2.
JAK is a family of cytoplasmic tyrosine kinases consisting of four isoforms, JAK1, JAK2, JAK3 and TYK2. According to studies, JAKs transduce cytokine-mediated signals through the family of signal transducers…
Serine palmitoyltransferase (SPT) is a key enzyme of sphingolipid metabolism. And it belongs to a family of pyridoxal 5'-phosphate-dependent alpha-oxoamine synthases. Sphingolipids are one of the major membrane lipids in…
The p38 MAPK pathway is a key regulatory factor for the biosynthesis of pro-inflammatory cytokines at the transcription and translation levels. There are four splicing variants in the p38 family:…