AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. Firstly, in vitro, AS2863619 is a potent Foxp3 inducer in Tconv cells. AS2863619…
In the NLR family, the NLRP3 inflammasome plays essential roles in the maturation and production of IL-1β and IL-18. Dysregulation of inflammasome and IL-1β affects the pathogenesis of many human…
The allele family CARD9 variant relates to increased or protected risk of inflammatory bowel disease (IBD). Moreover, the susceptible variant of CARD9 is related to the increase of NF-κ B-mediated…
Many pathogens have evolved to exploit very particular niches within the host optimally. Candida albicans provides a paradigm for the study of flexible and resilient pathogens. It is the most common…
Neutrophil granulocytes play an important role in regulating and fine-tuning inflammatory reactions. FPRs can recognize danger signals during microbial infections, inflammation, cancer, and tissue injury. In general, FPR recognizes formyl…