MAPKs include many serine-threonine kinases. One of the major MAPK cascades is p38 MAPKs. p38 MAPK can serve as a potential therapeutic target for the treatment of not only inflammatory…
Protein–protein interactions are major regulators of cell biology and important targets in drug discovery. Specifically, protein-protein interactions are driven by a small set of contact residues. Besides, small molecules that…
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant myeloid cell infiltrates. The immunosuppression, fibrosis, T cell dysfunction, and poor prognosis in patients with PDAC associate with these infiltrates. The cells…
Ionotropic (ligand-gated ion channel), P2X, and metabotropic P2Y receptors belong to P2 receptors. Up to now, eight subtypes of human P2Y receptors are P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11-14. P2…
Glycogen synthase kinase-3 (GSK-3) is a member of the serine/threonine kinase family. A number of human pathological conditions link to the upregulated GSK-3. This enzyme regulates a diverse array of…