![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/12/Orexin-A-is-a-Specific-Agonist-for-G-Protein-Coupled-Receptor-OX1R-2022-01-01-1600x915.png)
The orexin receptors are G-protein-coupled receptors (GPCRs), and consist of orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R) subtypes.…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/12/ARN19689-is-a-Highly-Selective-human-NAAA-Inhibitor-2021-12-18.jpg)
N-Acylethanolamine acid amidase (NAAA), an N-terminal cysteine hydrolase, primarily exists in the endosomal-lysosomal compartment of innate and adaptive immune cells.…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/11/Tapinarof-is-a-Natural-Aryl-Hydrocarbon-Receptor-AhR-Agonist-2021-12-07.jpg)
Tapinarof (GSK2894512) is a naturally-derived small molecule produced by bacterial symbionts of entomopathogenic nematodes. Especially, Tapinarof displays significant efficacy in…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/12/Rolipram-is-a-Selective-Phosphodiesterases-PDE4-Inhibitor-2021-12-03.jpg)
Phosphodiesterases (PDEs) are enzymes that convert cyclic nucleotides (cAMP and cGMP) to their corresponding 5′-AMP and 5′-GMP in order to…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/11/GYY4137-is-a-Slow-Releasing-H2S-Donor-with-Vasodilator-and-Antihypertensive-Activity-2021-11-26.jpg)
Hydrogen sulfide (H2S), a recognized environmental pollutant, comes from a wide range of sources. For example, H2S will be produced…