Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein encoded by the CCR8 gene in the human body. Besides, CCR8 is the chemokine receptor of CCL1. Moreover,…
C5a is an important inflammatory hypernociceptive mediator, acting by a mechanism independent of hypernociceptive cytokine release, but dependent on the presence of neutrophils. Especially, C5a is a complement activation product….
Proteasomes control several cellular processes. They regulate protein degradation, mediate protein homeostasis. Proteasome function is tuned between a ubiquitously expressed constitutive proteasome and an immuno-optimized form, or immunoproteasome. The constitutive…
Persistent or reactivated signaling by the androgen receptor drives the progression of prostate cancer to a deadly form of the disease, namely metastatic castration-resistant prostate cancer (mCRPC). The RAR-related orphan…
The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. Specifically, the complement system is a complex network, including the interaction…