HIV Archives - Immune System Research

GS-6207 is a First-In-Class HIV-1 Capsid Inhibitor with Long-Acting Potential

2019-12-04 Edward Jenner

Exceptional developments in combination antiretroviral therapy (cART) have transformed HIV/AIDS from a deadly pandemic to chronic and manageable disease. HIV-1 capsid (CA) has two structurally distinct domains, an N-terminal domain…

BRD-6929, a Selective HDAC 1/2 Inhibitor, Potentiates the Efficacy of GM Against Latent HIV-1

2019-09-10 Edward Jenner

Histone deacetylase (HDAC) enzymes, including subtypes comprising class I (HDAC1, HDAC2, HDAC3, and HDAC8) and class II (HDAC 4–7, HDAC9 and HDAC10), control the deacetylation of histone and non-histone proteins….

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GS-6207 is a First-In-Class HIV-1 Capsid Inhibitor with Long-Acting Potential

2019-12-04 Edward Jenner

BRD-6929, a Selective HDAC 1/2 Inhibitor, Potentiates the Efficacy of GM Against Latent HIV-1

2019-09-10 Edward Jenner