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HIV Infection Viral Immunology

Doravirine is a HIV-1 Inhibitor for Infection Research

Edward Jenner 2023-09-22

Reverse transcriptases (RTs) are enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases (RTs) use an RNA template and a short…

Chronic kidney disease HIV

Bis-T-23 is a HIV-I Integrase Inhibitor for HIV and CKD Research

Edward Jenner 2023-07-13

Chronic kidney disease (CKD) affects hundreds of millions of people worldwide. A common phenomenon is the presence of large amounts of high molecular weight plasma proteins in the urine. In…

HIV SARS-CoV

Nirmatrelvir (PF-07321332) is an Orally Active SARS-CoV 3CLpro Inhibitor for COVID-19 Research

Edward Jenner 2023-06-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. Firstly, the coronavirus 3-chymotrypsin-like protease (3CLpro) can control virus replication. Secondly, 3CLpro is responsible for cleaving…

HIV Infection

Lenacapavir (GS-6207) is an HIV-1 Capsid Inhibitor for Infection Research

Edward Jenner 2023-04-06

Capsid (CA) protein is a major virion-constituent of all retroviruses including human immunodeficiency virus type 1 (HIV-1). It is essential for early and late phases in the viral replication cycle.…

antibiotic Bacterial Fungal HIV Infection

Siamycin I, an HIV Fusion Inhibitor, Interacts with Lipid II and Inhibits Cell Wall Biosynthesis

Edward Jenner 2023-02-24

HIV is a virus that affects the immune system. HIV infects important cells in the human immune system, such as helper T cells (especially CD4+T cells), macrophages, and dendritic cells.…

Cancer Immunotherapy HIV Immunodeficiency Viral Immunology

Lefitolimod (MGN 1703) is a DNA-Based TLR9 Agonist and an Immune Surveillance Reactivator

Edward Jenner 2023-01-25

TLR9 is an important receptor existing in immune system cells (including dendritic cells, macrophages, and other antigen-presenting cells). TLR9 recognizes cellular DNA fragments containing unmethylated cytidine-phosphate-guanosine (CpG DNA) which only…

HIV Viral Immunology

NBD-14270 is a Potent HIV-1 Entry Antagonist

Edward Jenner 2022-11-03

HIV is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS). HIV infects vital cells in the human immune system such as helper T cells (specifically…

HIV Infection Viral Immunology

GSK3739936 is a Potent HIV-1 Allosteric Integrase Inhibitor

Edward Jenner 2022-09-27

HIV-1 integrase (IN) is an enzyme responsible for integrating the viral DNA copy of the viral RNA genome into the host chromatin. Specifically, IN is one of the main anti-virus…

HIV Infection

Aplaviroc (AK 602) is a CCR5 Antagonist

Edward Jenner 2022-05-07

Aplaviroc (AK 602), an SDP derivative, is a potent CCR5 antagonist. Additionally, the IC50s  are 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL, and HIV-1MOKW. In vitro, Aplaviroc exerts potent activity against HIV-1 strains.…

HIV Immunodeficiency RABV

Rottlerin is a Specific PKC Inhibitor

Edward Jenner 2022-01-07

Protein kinase C (PKC) is a family of protein kinase enzymes with 15 isoforms that can regulate the protein function. PKCs can control the function of otherproteins through the phosphorylation…

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  • PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH
  • Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research
  • Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research
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  • Doravirine is a HIV-1 Inhibitor for Infection Research

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You Missed

Pulmonary Arterial Hypertension (PAH)

PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH

Cancer Immune Metabolic Disease

Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research

Uncategorized

Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research

NASH obesity

Elafibranor is a PPARα/δ Agonist for Metabolic Disease Research

Immune System Research

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