Analgesia Archives - Immune System Research

SB-612111 is a Potent Human Opiate Receptor-Like Orphan Receptor (ORL-1) Antagonist

2020-06-10 Edward Jenner

Nociceptin, as a 17-amino acid peptide, is a potent endogenous agonist for the opiate receptor-like orphan receptor (ORL-1). It exhibits a high degree of structural homology to the classical opioid…

UNC3230 is a Selective and ATP-Competitive PIP5K1C Inhibitor

Phosphatidylinositol-4-phosphate 5-kinase type-1C (PIP5K1C) is a lipid kinase that regulates focal adhesion dynamics and cell attachment through the site-specific formation of phosphatidylinositol ,5-bisphosphate (PI4,5P2). Numerous pain-producing (pronociceptive) receptors signal via…

Immune System Research

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Category: Analgesia

SB-612111 is a Potent Human Opiate Receptor-Like Orphan Receptor (ORL-1) Antagonist

2020-06-10 Edward Jenner

UNC3230 is a Selective and ATP-Competitive PIP5K1C Inhibitor

2020-06-04 Edward Jenner