Degradation of proteins in mammalian cells via two distinct pathways: lysosome-dependent and proteasome-dependent. PR-39 is a proline- and arginine-rich antibacterial peptide. It is also a noncompetitive, reversible, and allosteric proteasome inhibitor. PR-39 reversibly binds…
Nosocomial infections can lead to mortality. They account for approximately 2 million patients per year in the United States. Gram-negative bacteria account for approximately two-thirds of nosocomial infections. Moreover, in…
SpCas9 is an RNA-guided DNA endonuclease and has a facile introduction of genomic alterations. The SpCas9 complex and guide RNA (gRNA) recognizes the substrate sequence via a protospacer adjacent motif…
The current treatment of bacterial infections is challenged by a dramatic increase of multidrug-resistant (MDR) strains. In addition to Gram-negative MDR pathogens cause infection, Gram-positive pathogens, such as Staphylococcus aureus,…
Staphylococcus aureus is a major bacterial human pathogen that causes a wide variety of clinical manifestations. Staphylococcus aureus is the leading cause of infections worldwide, and methicillin-resistant strains (MRSA) are…