As we all know, Farnesyl diphosphate synthase(FPPS) is an important drug target for bone resorption, cancer, and some infectious diseases. Besides, FPPS and undecaprenyl diphosphate synthase (UPPS) involves in bacterial…
Caenorhabditis elegans provides a potential for high throughput, live-animal screening of low molecular weight compound libraries. These are to identify molecules that target multiple cellular processes. The study of the C….
The bacterial enzyme UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC) catalyzes the first committed step of lipid A biosynthesis. Additionally, the process represents a promising target in the development of novel antibiotics against Gram-negative…
ATP binding cassette (ABC) transporters are found in all species. ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of integral membrane proteins that are responsible for the ATP-powered translocation of…
The alarming spread of multidrug resistance is due to a very limited number of pathways for existing antibiotics. Biotin biosynthesis is an antimicrobial development prospect because it is essential for…