The current treatment of bacterial infections is challenged by a dramatic increase of multidrug-resistant (MDR) strains. In addition to Gram-negative MDR pathogens cause infection, Gram-positive pathogens, such as Staphylococcus aureus,…
Staphylococcus aureus is a major bacterial human pathogen that causes a wide variety of clinical manifestations. Staphylococcus aureus is the leading cause of infections worldwide, and methicillin-resistant strains (MRSA) are…
SPR741, an antibiotic adjuvant that can permeabilize the Gram-negative membrane. In this article, we will briefly introduce this compound in vitro and in vivo. SPR741 lacks significant antibacterial activity as…
As we all know, Farnesyl diphosphate synthase(FPPS) is an important drug target for bone resorption, cancer, and some infectious diseases. Besides, FPPS and undecaprenyl diphosphate synthase (UPPS) involves in bacterial…
Caenorhabditis elegans provides a potential for high throughput, live-animal screening of low molecular weight compound libraries. These are to identify molecules that target multiple cellular processes. The study of the C….