PK (Pyruvate Kinase) is an enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP in glycolysis. Importantly, Pyruvate kinase deficiency is a glycolytic enzymopathy that is…
TLR9 is an important receptor existing in immune system cells (including dendritic cells, macrophages, and other antigen-presenting cells). TLR9 recognizes cellular DNA fragments containing unmethylated cytidine-phosphate-guanosine (CpG DNA) which only…
HIV protease, a homodimeric aspartyl protease, is an essential component of the Human Immunodeficiency Virus genome. HIV protease is responsible for cleaving the Gag and Gag-Pol polyproteins in a late…
Protein kinase C (PKC) is a family of protein kinase enzymes with 15 isoforms that can regulate the protein function. PKCs can control the function of otherproteins through the phosphorylation…
Exceptional developments in combination antiretroviral therapy (cART) have transformed HIV/AIDS from a deadly pandemic to chronic and manageable disease. HIV-1 capsid (CA) has two structurally distinct domains, an N-terminal domain…
Human immunodeficiency virus (HIV) is a threat to humans and a serious issue for public health worldwide. Especially, acquired immune deficiency syndrome (AIDS) is the most serious stage of HIV…
In previous blog “MLT-747, an Allosteric MALT1 Inhibitor for Immunodeficiency Research”, we introduced MLT-747 as a potent, selective, allosteric inhibitor of MALT1, which could rescue function in an immune deficient…
Immunodeficiency is a state, in which the immune system’s ability is absent. It is not able to fight against cancer or infectious diseases. MALT1 is the human paracaspase, with the…