P38 MAPKs is a class of kinases responsive to stress stimuli. It has four types, including p38α (MAPK14), p38β (MAPK11), p38γ (MAPK12/ERK6), and p38δ (MAPK13/SAPK4). The kinases involve an inflammatory…
A study from Xiaojing Wang discovered and identified a novel Btk inhibitor G-744 that has potential to treat arthritis. Bruton’s tyrosine kinase (Btk) plays an indispensable role in the function…
In the previous article “KRN5 is a Nuclear Factor of Activated T Cells 5 (NFAT5) Suppressor”, we introduced a novel NFAT5 suppressor KRN5. And the suppressor is the derivative of…
Nuclear factor of activated T cells 5 (NFAT5) participates in the pathogenesis of various human diseases, including cancer and arthritis. However, there are no therapeutic drugs that inhibit the activity…