SARS-CoV Archives - Immune System Research

GS-441524, a FIPV Inhibitor and the Predominant Metabolite of Remdesivir, is More Effective Against Covid-19

2020-07-16 Edward Jenner

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Specifically, Coronavirus is one of the main pathogens that mainly target the human…

PB28 is a Selective σ2 Receptor Agonist with High Affinity

2020-06-30 Edward Jenner

Sigma Ligands has cytotoxic activity in vitro and is able to induce ceramide/caspase-independent apoptosis. In addition, these ligands down-regulate P-glycoprotein (P-gp) mRNA levels in some mouse and human models. In…

ML188 is a Noncovalent Inhibitor of the SARS-CoV 3CL Protease

2020-05-26 Edward Jenner

Coronaviruses (CoV) are large plus-strand RNA viruses. They cause medical disorders such as the common cold, lower respiratory tract infections, and diarrhea. The SARS-CoV genome encodes a large polyprotein. Two…

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