Guanylate cyclase (guanylyl cyclase, GC), which catalyzes the formation of cGMP from GTP, exists in both the soluble and particulate fractions of cells. The GC family consists of particulate GC…
In this article, we will introduce a potent and orally available SGLT2/1 Inhibitor, Sotagliflozin (LX-4211). It exhibits IC50 values of 0.0018 µΜ and 0.036 µM for SGLT-2 and SGLT-1, respectively. Sotagliflozin's…
Autophagy is a conserved degradation pathway. Autophagy maintains cellular homeostasis in the cell by directing the clearance of old and abnormal proteins or organelles. However, autophagy dysregulates leads to many…