M1002 is a HIF-2 Agonist
Hypoxia is a state where oxygen availability/delivery is below the level necessary to maintain physiological oxygen tension for a particular tissue. It is well-established that when tissue demand exceeds its…
Hypoxia is a state where oxygen availability/delivery is below the level necessary to maintain physiological oxygen tension for a particular tissue. It is well-established that when tissue demand exceeds its…
URAT1 (urate transporter 1), a member of the OAT (organic anion transporter) family, where is localized to the apical (brush border) membrane of renal proximal tubular cells. Moreover, URAT1 mediates…
Na+/Ca2+ exchanger (NCX) is an ion transporter that is important in regulating intracellular Ca2+ homeostasis in various tissues. It exchanges Na+ and Ca2+ in either the Ca2+ exit or Ca2+ entry mode. The three subtypes…
mGluR (metabotropic glutamate receptor) is a type of glutamate receptor that are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or…
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare bone marrow failure disorder. It manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias. Destruction of red blood cells by the complement system (an…
The human immunodeficiency virus (HIV) is a retrovirus. It can cause acquired immunodeficiency syndrome (AIDS), and weaken people's defense against many infections and some types of cancer. This virus kills…
Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of PDE are referring to cyclic nucleotide phosphodiesterase. while, the superfamily of PDE enzymes is classified into…
Glycosidases are enzymes catalyzing the hydrolysis of glycosidic bonds in complex sugars. They take part in the biosynthesis of the oligosaccharide chains and quality control mechanisms in the endoplasmic reticulum…
Calcium-activated chloride channels (CaCCs) are always expressed in epithelial and nonepithelial cells. They are involved in epithelial fluid secretion, sensory signal transduction, smooth muscle contraction, oocyte fertilization, and other functions.…
Atopic dermatitis is a chronically relapsing inflammatory skin disease. The characteristics of atopic dermatitis are eczema and even pruritus. The mechanism of itching evoked in atopic dermatitis is still not…