Methisazone (Marboran) is a compound of the class of N-aminomethyl-isatin-beta-thiosemicarbizones. It acts as an antiviral agent, working via inhibiting mRNA and protein synthesis. In the early 1950s, Methisazone has been found to…
HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the…
Tuberculosis, one of the oldest known human diseases, is a potentially serious infectious disease that mainly affects the lungs. It is still one of the major causes of mortality since…
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. In addition, RTKs are not only critical regulators of normal cellular processes,…
CCR3 is a chemokine receptor. CCR3 is abundant in eosinophils, mast cells, basophils, and human Th2-like T lymphocyte subsets β Chemokine receptor. Besides, CCR3 is an eotaxin receptor, but it…
Zatebradine (UL-FS-49) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 of 1.96 µM. Zatebradine reduces the dose-dependently the amplitude of the cardiac pacemaker current (If),…
Darapladib (SB-480848) is a potent, selective, freely reversible, non-covalently bound, orally active inhibitor of Lp-PLA2 with an IC50 of 0.25 nM, and it serves as a predictive biomarker of inflammation in cardiovascular…
HIF (Hypoxia-inducible factor) is a transcriptional factor that plays a role in the physiologic responses to hypoxia. Most oxygen-breathing species express the highly conserved transcriptional complex HIF-1. HIF-1 is a…
Monoamine oxidases (MAOs) are a family of enzymes that catalyze the oxidation of monoamines. Additionally, they including MAO-A and MAO-B. MAOs plays important role in the inactivation of neurotransmitter. Therefore, their…