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PRE-084 is a S1R Agonist for Cardiovascular and Neurological Disease Research

Edward Jenner 2023-05-24

The sigma-1 receptor (σ1R, S1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. Moreover, the…

Epilepsy

LY456236 is an Orally Active mGlu1 Receptor Antagonist for Neurological Disease Research

Edward Jenner 2023-04-25

Epilepsy is one of the most common neurological diseases in the world. Firstly, Epilepsy affects people of all ages, races, social classes, and geographical locations. Secondly, Epilepsy is a disease…

Epilepsy Neurological Disease

JNJ-56022486 is an Orally Active Negative AMPA Receptor Modulator for Epilepsy Research

Edward Jenner 2023-03-07

Glutamate is the primary excitatory neurotransmitter in the mammalian brain. AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid) is the subtype of glutamate receptors and also is a ligand-gated ion channel. It expresses primarily on…

Alzheimer Epilepsy Inflammation Ischemia Multiple Sclerosis Neurological Disease

Fuzapladib (IS-741) is A Potent Phospholipase A2 Inhibitor

Edward Jenner 2023-02-16

Phospholipase is a member of a very complex group of enzymes that break down phospholipids into fatty acids and other compounds. Phospholipase is defined by the enzymatic reaction they catalyze.…

Analgesia Cognitive Disorders Epilepsy Neurological Disease Schizophrenia

SSR504734 is an Orally Active, Selective and Reversible GlyT1 Inhibitor

Edward Jenner 2022-09-22

Glycine transporters (GlyTs) are the Na+/Cl--dependent plasmalemmal neurotransmitter transporters. GlyTs comprise GlyT1 and GlyT2. They serve to terminate the signaling of glycine by mediating its reuptake from the synaptic cleft…

Epilepsy

AZD7325 is an Orally Active GABAAα2,3 Positive Allosteric Modulator

Edward Jenner 2020-05-06

Benzodiazepines are useful in the research of anxiety disorders. Benzodiazepines also is useful for symptomatic relief of various anxiety states related to diverse psychiatric disorders, including mood, psychotic and personality…

Epilepsy

ML 297 is a Selective GIRK Potassium Channel Activator with Antiepileptic Properties

Edward Jenner 2020-02-15

The G-protein activated, inward-rectifying potassium (K+) channels, “GIRKs”, are a family of ion channels (Kir3.1-Kir3.4). Besides, GIRKs are comprised of various homo- and heterotetrameric combinations of four different subunits. In addition, These…

Epilepsy Inflammation

TG4-155 is a Brain Penetrant EP2 Receptor Antagonist

Edward Jenner 2019-07-31

Prostaglandin EP2 receptor (PGE2) is a potential neuroprotection target in epilepsy and other inflammation-related neurological disorders. Activation of PGE2 subtype EP2 promotes inflammation. The EP2 receptor widely expresses in both…

Autoimmune Disorders Epilepsy

Belnacasan is an Orally Active ICE/caspase-1 Inhibitor for Treatment of Inflammatory and Autoimmune

Edward Jenner 2019-06-01

Familial cold autoinflammatory syndrome is a condition that causes episodes of fever, skin rash, and joint pain after exposure to cold temperatures. In people with familial cold autoinflammatory syndrome, the…

Recent Posts

  • PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH
  • Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research
  • Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research
  • Elafibranor is a PPARα/δ Agonist for Metabolic Disease Research
  • Doravirine is a HIV-1 Inhibitor for Infection Research

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You Missed

Pulmonary Arterial Hypertension (PAH)

PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH

Cancer Immune Metabolic Disease

Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research

Uncategorized

Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research

NASH obesity

Elafibranor is a PPARα/δ Agonist for Metabolic Disease Research

Immune System Research

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