![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/12/CC-92480-is-a-Cereblon-E3-Ubiquitin-Ligase-Modulating-Drug-with-Antimyeloma-Activity-2019-12-10.jpg)
Immunomodulatory agents (IMiDs) are a class of immunomodulatory drugs. Thalidomide analogs have induced significant antimyeloma effects via immune-modulation, antiangiogenesis, and…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/11/GNF362-is-a-Highly-Selective-and-Orally-Active-Itpkb-Inhibitor-2019-12-3.jpg)
In mature lymphocytes, the Spatio-temporal regulation of Ca2+ modulates signaling pathways. They serve to control a variety of cellular responses, such…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/12/PF-06651600-is-a-Orally-Active-and-Covalent-JAK3-Selective-Inhibitor-2019-12-2.jpg)
JAK/STAT-dependent cytokines are essential for the development, proliferation, and function of T-cells. The JAK family of nonreceptor tyrosine kinases is…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/11/PD-407824-is-a-Dual-Chk1-and-WEE1-Inhibitor-2019-11-31.jpg)
Bone morphogenetic proteins (BMPs) are important regulators of embryonic development and stem cell fate decisions. In human ESCs, BMP4 promotes…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/11/MYCi975-an-Orally-Active-MYC-Inhibitor-Enhances-Immunotherapy-2019-11-22.jpg)
MYC proteins include MYC (also known as c-MYC), MYCL, and MYCN. They play critical roles in tumorigenesis and therapeutic resistance. MYC…