SKA-111 is a Potassium Phannel KCa3.1 Activator for Cardiovascular Disease Research
SKA-111 is a highly selective KCa3.1 activator, with hypotensive effect and vasodilator effect.
Allisartan isoproxil is an AT1R Inhibitor for Cerebrovascular Damage Research
Angiotensin II Type 1 Receptor (AT1R) belongs to the G protein-coupled receptor family and is an important part of the renin-angiotensin-aldosterone system (RAAS). The RAAS regulates a variety of physiological…
Sparsentan (RE-021) is a Dual Angiotensin II and Endothelin A Receptor Antagonist
Angiotensin is a peptide hormone that causes blood vessels to constrict and blood pressure to increase. It is part of the renin-angiotensin system that regulates blood pressure. Among them, angiotensin…
Sparsentan (RE-021) is a Potent Dual Angiotensin II and Endothelin A Receptor Antagonist
The angiotensin II receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. Angiotensin II receptors include four subtypes: AT1, AT2, AT3 and AT4. They are…
NCX 470 is a Nitric Oxide (NO)-Donating Prostaglandin Analogue
Glaucoma is a type of eye disease that may cause optic nerve damage and vision loss. The predominant risk factor for the progression of glaucoma is an elevated intraocular pressure…
TRV055, a G-protein-biased Agonist, is a Gq-biased Ligand of AT1R
The angiotensin II (Ang II) receptors, AT1R and AT2R, belong to the family of G protein-coupled receptors. Angiotensin II is the ligand of AT1R and AT2R. The two receptors are…
T16A(inh)-C01 is an Inhibitor of TMEM16A (ANO1)
Calcium-activated chloride channels (CaCCs) are always expressed in epithelial and nonepithelial cells. They are involved in epithelial fluid secretion, sensory signal transduction, smooth muscle contraction, oocyte fertilization, and other functions.…