Echinococcins are a class of antifungal drugs. These drugs inhibit glucan synthase, which is responsible for synthesis β1-3 linked glucans. Meanwhile, echinococcin inhibits 1,3 through noncompetitive inhibition- β Glucan synthase…
As we all know, the SARS-CoV-1 virus caused the 2002-2004 SARS outbreak. Today, we will introduce a virus -- SARS-CoV-2. SARS-CoV-2 is related to the SARS-CoV-1 virus. SARS-CoV-2 belongs to…
Calcitonin gene-related peptide (CGRP) is a member of the calcitonin peptide family. CGRP has two main forms (α And β). Specifically, CGRP is a highly effective vasodilator. It is important…
IL-6 (Interleukin 6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. Besides, IL-6 signals through a cell-surface type I cytokine receptor complex consisting of…
JNJ-61803534 is a potent and orally active RORγt inverse agonist. JNJ-61803534 exhibits anti-inflammatory activity. It inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions. JNJ-61803534 (1 nM-1…
mAChRs (muscarinic acetylcholine receptors) are G-protein-coupled receptors and exist in five subtypes. The M1, M3 and M5 receptors are excitatory receptors. Meanwhile, M2 and M4 receptors inhibit neuronal firing by…
MPDE5 is an enzyme derived from phosphodiesterases, present in various tissues, including rods and cones of the retina, and belongs to the large family of cyclic nucleotide PDEs that catalyze…
Omaveloxolone (RTA 408) is an agent for Friedreich's Ataxia. And it acts through a combination of activation of the antioxidative transcription factor Nrf2 and inhibition of the pro-inflammatory transcription factor…
Type I interferons are important innate and adaptive immune response factors. It derivates from infected cells and in turn, induces the cells to create an antimicrobial environment that limits the…
Anemia is a common debilitating complication arising from diverse causes, including myelodysplastic syndromes (MDS), thalassemia, cancer chemotherapy, chronic kidney disease and hemorrhage. Although endogenous erythropoietin (EPO) and its cognate receptor…