MS48107 is a Selective GPR68 PAM
G protein-coupled receptor 68 (GPR68) is originally discovered as a clinically related receptor in an ovarian cancer cell line. GPR68 widely expresses in most cells and tissues, including the spleen,…
G protein-coupled receptor 68 (GPR68) is originally discovered as a clinically related receptor in an ovarian cancer cell line. GPR68 widely expresses in most cells and tissues, including the spleen,…
IRAK-4 (interleukin-1 receptor-associated kinase 4) is a protein kinase involved in signal transduction of innate immune response from toll-like receptors. Specifically, it also supports signal transduction from T cell receptors.…
Neutrophil elastase (HNE) is a serine protease, similar to chymotrypsin, and has a wide range of substrate specificity. Specifically, secreted by neutrophils and macrophages during inflammation, it destroys bacteria and…
The highly active antiretroviral therapy (HAART) can transform the human immunodeficiency virus (HIV) infection into a manageable chronic disease in a little over a decade. The combination of antiretroviral drugs…
Cyclic AMP (cAMP) is a universal second messenger in cells of all biological systems. Specifically, cAMP homeostasis is affected by synthesis, interaction, and degradation, and is realized by the multigene…
The AAA+ ATPase p97 is essential to a wide range of cellular functions. The p97 acts downstream from ubiquitin signaling events and utilizes the energy from ATP hydrolysis to extract…
Retinoblastoma protein (Rb), a tumor suppressor protein, is dysfunctional in several major cancers. Specifically, one of the functions of Rb is to prevent excessive cell growth by inhibiting cell cycle…
The negative feedback system regulates the 5-Hydroxytryptamine 5-HT release. Besides, the negative feedback system is mediated by autoreceptors located on neuronal terminals and cell bodies. The terminal autoreceptor in the…