Hepatitis C is a blood-borne infection that can ultimately result in severe liver diseases, including fibrosis, cirrhosis, and hepatocellular carcinoma. The chronic nature of the disease and the significant possibility…
Epidermal growth factor receptor (EGFR) is a transmembrane protein and a member of the ErbB receptor family. Specifically, EGFR is a tyrosine kinase in various tissues and mediates cell proliferation,…
Hepatitis C virus (HCV) is a human pathogen with high morbidity. The HCV NS3/4A protease is essential for viral replication and is one of the top three drug targets. BMS-986144…
The major cause of chronic liver disease is the Hepatitis C virus (HCV). HCV is able to establish a chronic infection that may lead to liver fibrosis, liver cirrhosis, and…
Enteroviruses comprise several pathogens. They cause a large variety of clinical manifestations that range from mild illnesses to more serious or even life-threatening diseases. They include meningitis, encephalitis, myocarditis, pancreatitis, acute…
RNA virus represents an enormous public health problem. Although drug therapy is essential to mitigate the significant morbidity and mortality associated with these viruses, the number of antiviral drugs is…
BI-1230 is a potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. It also shows good Pharmacokinetic(PK)…
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and associated morbidity and mortality worldwide. HCV associates with an increased incidence of liver fibrosis, cirrhosis, and…
Chronic hepatitis C (CHC) virus infection continues to be a significant health burden, and 2–3% of the global population infected by the hepatitis C virus (HCV). The innate immune response…