A noradrenaline reuptake inhibitor (NRI), is a type of drug that blocks the action of the norepinephrine transporter (NET). And NRI can increase adrenergic neurotransmission. Furthermore, NRIs have psychostimulatory effects…
MCH1R (melanin-concentrating hormone 1 receptor) is one of the melanin-concentrating hormone receptors found in all mammals. What's more, The protein encoded by this gene, a member of the G protein-coupled…
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs). They mediate both excitatory and inhibitory neurotransmission. The 5-HT receptors modulate the release…
Monoacylglycerol lipase (MAGL) is a 33 kDa membrane-related member of serine hydrolase superfamily. Besides, it contains the classical GXSXG common sequence common to most serine hydrolases. MAG is the main…
ARC 239 is a selective α2B/2C adrenoceptor antagonist. Besides, ARC 239 binds to CHO cell membranes expressing human recombinant α2A-, α2B- or α2C-adrenoceptor subtypes. α2 adrenoceptor is a G protein-coupled…
TGF-β1 is a cytokine transforming growth factor β Polypeptide member of the superfamily. Specifically, it is a secretory protein with a variety of cellular functions, including the control of cell…
The nuclear retinoic acid receptors (RARs) are transcriptional transregulators, and belong to the family of nuclear receptors. RARs consist of three subtypes, α (NR1B1), β (NR1B2), and γ (NR1B3), encoded…
Tropomyosin receptor kinases (Trk) family includes TrkA, TrkB and TrkC, can be activated by hormones of the neurotrophin family, nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and…
Cytomegalovirus (CMV) is a genus of Herpesvirales. Several species of CMV have been identified and classified for different mammals, including human CMV (HCMV), chimpanzee CMV (CCMV), mouse CMV (MCMV), guinea pig…
Tumor necrosis factor (TNF, also referred to as TNFα) is a pro-inflammatory cytokine belonging to a family of trimeric proteins. TNF exerts its biological functions through activating distinct signaling pathways…