Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs). They play an important role in the host's innate immune response and immunity homeostasis. Among them, NLRP3 belongs…
Ulcer is caused by discontinuity or break in a bodily membrane, which can damage normal function of the affected organ. Besides, it is induced by sloughing out of inflamed necrotic…
Etrasimod is a potent, selective, and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor. And the IC50 value is 1.88 nM in CHO cells. Firstly, in vitro, In CHO cells expressing HA-tagged…
NLRX1 is a highly conserved nucleotide-binding domain (NBD) and a member of the leucine-rich repeat (LRR) family (NLR). Specifically, NLRX1 is an intracellular protein that plays a role in the…
The allele family CARD9 variant relates to increased or protected risk of inflammatory bowel disease (IBD). Moreover, the susceptible variant of CARD9 is related to the increase of NF-κ B-mediated…
As we all know, Colitis is a kind of inflammatory diseases. Sometimes it is acute and long term, makes patients painful. EP4 receptor (Prostaglandin E2 receptor 4) is a prostaglandin…