Remibrutinib is an Orally Active BTK Inhibitor for Chronic Urticaria Research
Remibrutinib is a potent and orally active BTK inhibitor for Chronic urticaria (CU) research.
IBMX is a Broad-Spectrum PDE Inhibitor for Renal Fibrosis Research
Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging and in chronic kidney disease (CKD). The US Centers for Disease Control and Prevention project that 47% of…
Chloroquine is an Autophagy and TLRs Inhibitor for Malaria and Rheumatoid Arthritis Research
Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Intersetingly, Chloroquine not only a excellent anti-inflammatory agent, but also demonstrates more activities about cancer,…
Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research
Oxidative stress describes an imbalance between reactive oxygen species (ROS) synthesis and antioxidants. Normally, cells possess antioxidant defense systems that include ROS degrading molecules (ROS scavengers), such as uric acid,…
Cabozantinib is an Orally Active VEGFR2/MET Inhibitor for Tumor Research
An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis). Some angiogenesis inhibitors are endogenous and a normal part of the body's control and others are obtained exogenously through pharmaceutical drugs or diet. While…
Vadadustat is an Oral Active HIF-PH Inhibitor for Anemia Research
HIFs (Hypoxia-inducible factors) are transcription factors that respond to changes in available oxygen in the cellular environment, to be specific, to decreases in oxygen, or hypoxia. The HIF signaling cascade…
HX630 is a Potent RXR Agonist for Cushing’s Diseases Research
The retinoic acid X receptor (RXR) is a core member of the nuclear receptor protein family. Acts as a ligand-regulated transcription factor. RXR, the heterodimeric partner of VDR, is a…
Darapladib is a Potent Lp-PLA2 Inhibitor for Atherosclerosis and Cancer Research
Darapladib is an orally active, selective and reversible Lp-PLA2 inhibitor, with an IC50 value of 0.25 nM.
SLMP53-2 is a Mutant p53 Reactivator for Cancer Research
p53 (Tumor protein P53; cellular tumor antigen p53; transformation-related protein 53 (TRP53)) is a regulatory protein. The p53 proteins are crucial in vertebrates, where they prevent cancer formation. As such,…
PRE-084 is a S1R Agonist for Cardiovascular and Neurological Disease Research
The sigma-1 receptor (σ1R， S1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. Moreover, the…