M62812 is a TLR4 Signaling Inhibitor for Sepsis Research
Patients are often at risk for sepsis in intensive care units as a major complication after infection and/or surgery mostly due to trauma, burn injury, pancreatitis, etc. Sepsis occurs when…
Patients are often at risk for sepsis in intensive care units as a major complication after infection and/or surgery mostly due to trauma, burn injury, pancreatitis, etc. Sepsis occurs when…
JAK is a family of cytoplasmic tyrosine kinases consisting of four isoforms, JAK1, JAK2, JAK3 and TYK2. According to studies, JAKs transduce cytokine-mediated signals through the family of signal transducers…
Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. Importantly, JAK1 and JAK2 are one of the human tyrosine kinase…
Kinases typically integrate signaling events down-stream of multiple cytokine receptors. Hence, kinase inhibitors distinguish themselves from cytokine-targeted biologicals by their capacity to modulate multiple signaling pathways simultaneously. IL-1 receptor (IL-1R)–associated…
Receptor-interacting protein (RIP) kinases are a group of threonine/serine protein kinases. There are seven members of the RIPK family, RIPK1-7. RIP kinases are cellular signaling molecules that are critical for…
Arachidonic acid 15 lipoxygenases (ALOX15) is a key enzyme relevant to the synthesis of specific resolution media (SPM). Specifically, it includes lipoxygenase (LXs), decomposers (Rvs), protective elements, and maresins. 15-LOX-1,…
Dopamine Receptors belong the family of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). There are at least five subtypes of dopamine receptors, D1, D2,…
Sirtuin (Sir2 proteins) is a class of proteins. And it possesses either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in…
Stroke is the most serious and potentially deadly neurological disease and the most important factor leading to permanent disability in adults, significantly affecting the quality of life of stroke patients.…
Coronavirus disease 2019 (COVID-19) has caused a huge threat to global public health. Moreover, the constant emergence of variants of concern (VOCs) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…