Prostaglandin EP2 receptor (PGE2) is a potential neuroprotection target in epilepsy and other inflammation-related neurological disorders. Activation of PGE2 subtype EP2 promotes inflammation. The EP2 receptor widely expresses in both…
Interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK or TXK) are essential mediators of intracellular signaling in both normal and neoplastic T-cells and natural killer (NK) cells. Thus, ITK…
Systemic sclerosis is an autoimmune disease of the connective tissue. The symptom is thickening of the skin due to collagen accumulation or injuries to small arteries. As we all know,…
Necroptosis is a form of regulated necrosis controlled by receptor-interacting kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL). Necroptosis closely associates with pathologies including inflammatory diseases, neurodegenerative…
Chronic obstructive pulmonary disease (COPD) is a kind of lung disease. The symptoms are obvious, including shortness of breath and cough with sputum production. It always worsens over time. p38…
RIPK1 (receptor-interacting serine/threonine protein kinase 1) belongs to the receptor interacting protein kinases family, which contains seven members. RIPK1 plays a vital role in cell survival and cell death. It…
Malaria has been a military problem throughout history capable of causing epidemics that stop military operations. Particularly, malaria has had a greater impact on world history than any other infectious…
Phosphoinositide 3-kinase (PI3K) plays an indispensable role in the signal transduction of numerous cellular functions via the formation of the second messenger PIP3. In previous blogs, I have introduced a…
The phosphatidylinositol-3-kinase (PI3K) signal transduction pathway plays an indispensable role in different cellular processes involving metabolism, proliferation, differentiation or activation. Therefore, targeting PI3K pathway represents an interesting approach in diseases…
Glucocorticoids belong to a class of corticosteroids, a kind of steroid hormones. They function by binding to the glucocorticoid receptor (GR). So, these steroid hormones play important role in the…