Arachidonic acid 15 lipoxygenases (ALOX15) is a key enzyme relevant to the synthesis of specific resolution media (SPM). Specifically, it includes lipoxygenase (LXs), decomposers (Rvs), protective elements, and maresins. 15-LOX-1,…
nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. In mammals, analysis of cDNA proved existence of 17 homologues of nAChR's subunits…
Opioid Receptors are G protein-coupled receptors (GPCRs). They mediate the response of most hormones, neurotransmitters, and drugs. Therefore, they play important role in sensory perception of vision, taste, and olfaction.…
Microglia is a kind of resident immune cell in the central nervous system (CNS) parenchyma. microglia remain in a quiescent state Under normal physiological conditions. Besides, Brain injury and some…
Glutamate is a predominant neurotransmitter released from excitatory neurons related to the fast synaptic excitation. The released glutamates diffuse across the synaptic cleft and generate fast EPSPs through binding to…
N-methyl-D-aspartate (NMDA) receptors, a family of L-glutamate receptors, play an important role in learning and memory, and are critical for spatial memory. NMDA receptor antagonists exhibit a neuroprotective effect in…
N-acetylcysteine amide (NACA) is the amide derivative of N-acetylcysteine (NAC) that is rapidly converted to NAC after systemic administration. N-acetylcysteine amide has emerged as a promising thiol antioxidant for multiple…
Transient receptor potential (TRP) channels are large and nonselective cation channels. It can respond to a wide range of chemical and physical stimuli and biophysical properties. TRPM3 acts as a…
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the central nervous system (CNS) of vertebrates. Specifically, dopamine receptors not only activate different effectors through G-protein…
AMPA receptors are ionic transmembrane receptors of glutamate, which mediate rapid synaptic transmission in the central nervous system (CNS). Specifically, AMPAR exists in many parts of the brain and is…