![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/02/BMS-986202-is-an-Orally-Active-Tyk2-Inhibitor-that-Binds-to-Tyk2-JH2-2021-02-06.jpg)
Tyrosine kinase 2 (Tyk2) is a non-receptor tyrosine kinase belonging to the Janus kinase (JAK) family. Specifically, the mammalian JAK…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/07/BMS-986251-is-an-Orally-Active-and-Selective-RORγt-Inverse-Agonist-2020-07-07.jpg)
Retinoic acid-related orphan receptor γt (RORγt) is a nuclear hormone receptor (NHR) and belongs to the RORγ family. It exists…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/03/CCG-203971-is-a-Second-Generation-RhoA-MRTF-A-Inhibitor-with-Antifibrotic-Effect-2020-03-21.jpg)
Metastasis is the major driver in cancer-related deaths. Metastases involve dysregulation of numerous cellular processes. Importantly, blockade of RhoC prevents…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/11/AS2863619-a-Foxp3-Inducer-is-an-Orally-Active-CDK819-Inhibitor-2019-11-28.jpg)
AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. Firstly, in vitro,…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/11/Remibrutinib-is-an-Orally-Active-BTK-Inhibitor-for-the-Chronic-Urticaria-Treatment-2019-11-09.jpg)
Chronic urticaria is a heterogeneous, persistent, and severely debilitating disease. Bruton’s tyrosine kinase (BTK) is a non-receptor kinase that plays…