Metastasis is the major driver in cancer-related deaths. Metastases involve dysregulation of numerous cellular processes. Importantly, blockade of RhoC prevents cellular invasion in breast and prostate cancer models. Especially, RhoA…
AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. Firstly, in vitro, AS2863619 is a potent Foxp3 inducer in Tconv cells. AS2863619…
Chronic urticaria is a heterogeneous, persistent, and severely debilitating disease. Bruton’s tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling. Especially, BTK is critical…
RORγ (gene name RORC) is an orphan nuclear receptor (NR). Various metabolic processes regulate its expression and involvement. Meanwhile, RORγ is also a key player in the immune system. The…
The retinoic acid-related orphan receptor (ROR) isoforms RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3) are members of the steroid nuclear hormone receptor superfamily. RORs play prominent roles in a variety…