AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. Firstly, in vitro, AS2863619 is a potent Foxp3 inducer in Tconv cells. AS2863619…
Chronic urticaria is a heterogeneous, persistent, and severely debilitating disease. Bruton’s tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling. Especially, BTK is critical…
RORγ (gene name RORC) is an orphan nuclear receptor (NR). Various metabolic processes regulate its expression and involvement. Meanwhile, RORγ is also a key player in the immune system. The…
The retinoic acid-related orphan receptor (ROR) isoforms RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3) are members of the steroid nuclear hormone receptor superfamily. RORs play prominent roles in a variety…
BMS-582949 was identified as a highly selective p38α MAP kinase inhibitor as early in 2010. Moreover, it has entered into clinical trials for further development and clinical studies in inflammatory…