Striatal-enriched protein tyrosine phosphatase (STEP) is a CNS-rich protein associated with a variety of neurological and neuropsychiatric disorders. Firstly, it is expressed exclusively in the central nervous system. Then, it…
Phospholipase is a member of a very complex group of enzymes that break down phospholipids into fatty acids and other compounds. Phospholipase is defined by the enzymatic reaction they catalyze.…
Nuclear factor kappa B (NF-κB) family transcription factors are the master regulators. NF-κB is indispensable for a wide variety of biological processes including inflammation and the immune system. NF-kB functions…
Double leucine zipper kinase (DLK, MAP3K12) and leucine zipper Carrying kinase (LZK, MAP3K13) are two homologous mitogen-activated protein kinases. They are regulators of neuronal apoptosis and axon degradation. And also…
Tau (Tubulin-associated unit) is a microtubule-associated protein (MAP) that is primarily present in axons. Besides, Tau is a multi-functional protein. Particularly, It takes part in the cross-linking and regulation of…
nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. In mammals, analysis of cDNA proved existence of 17 homologues of nAChR's subunits…
RIPK1 (Receptor-interacting serine/threonine-protein kinase 1), a 76-kDa protein, is an essential mediator of cell death and inflammation. This protein has a N-terminal kinase domain, a C-terminal death domain, and an…
The endogenous cannabinoid system consists of endogenous cannabinoids, cannabinoid receptors, and enzymes that synthesize and degrade endogenous cannabinoids. Specifically, many effects of cannabinoids and endogenous cannabinoids are mediated by two…
Microglia is a kind of resident immune cell in the central nervous system (CNS) parenchyma. microglia remain in a quiescent state Under normal physiological conditions. Besides, Brain injury and some…
AAlzheimer's disease (AD) is a neurodegenerative disease, characterized by progressive memory loss. In AD patients' brain, the Aβ-containing plaques and tau-containing neurofibrillary tangles exhibit significant accumulation. Aβ is primarily generated…