The CC-type chemokine receptor 1 (CCR1) is a chemokine receptor of significant importance in human health. CCR1 is a protein that in humans is encoded by the CCR1 gene. Moreover,…
Cyclooxygenase (COX) -2 is an inducible form of COX, and it involves in inflammation. In addition, Malignant mesothelioma (MM) is a fatal malignancy with an estimated incidence of 3,000 cases…
Biologic agents are highly effective therapies. It greatly improves the standard of care for patients with rheumatoid arthritis (RA). Even with the significant improvement in care, the maximal benefit has…
In mature lymphocytes, the Spatio-temporal regulation of Ca2+ modulates signaling pathways. They serve to control a variety of cellular responses, such as activation, differentiation, effector function, and cell death. Thus, targeting…
JAK/STAT-dependent cytokines are essential for the development, proliferation, and function of T-cells. The JAK family of nonreceptor tyrosine kinases is composed of four isoforms: JAK1, JAK2, JAK3, and TYK2. Functioning…