![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/02/UCB-9260-Inhibits-TNF-Signalling-by-Stabilising-an-Asymmetric-form-of-the-Trimer-2021-02-10.jpg)
Tumor necrosis factor (TNF) is a cytokine belonging to a family of trimeric proteins. This factor acts as a key…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/01/GSK620-is-a-Potent-and-Orally-Active-pan-BET-BD2-Inhibitor-2020-01-08.jpg)
The therapeutic potential of extra terminal domain inhibitor (iBET) has increasing studies both in oncology and immunoinflammatory. Moreover, iBETs are…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/12/HS271-is-a-Highly-Potent-Orally-Active-and-Selective-IRAK4-Inhibitor-2020-12-24.jpg)
IRAK-4 (interleukin-1 receptor-associated kinase 4) is a protein kinase involved in signal transduction of innate immune response from toll-like receptors.…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/09/SP-100030-is-a-Potent-NF-κB-and-Activator-Protein-1-AP-1-Inhibitor-2020-10-01.jpg)
Nuclear factor-κB (NF-κB) represents a family of inducible transcription factors. The transcription factor NF-κB regulates multiple aspects of innate and…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/07/RVX-297-is-an-Orally-Bioavailable-and-Selective-BET-BD2-Inhibitor-2020-07-22.jpg)
Proinflammatory stimuli induce rapid transcriptional responses. They are essential for host defense from infection. An inflammatory response involves a variety…