Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors.…
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. They mediate both excitatory and…
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory…
The U.S. Food and Drug Administration approved Zuranolone, the first oral medication indicated to treat postpartum depression (PPD) in adults. PPD is a major depressive episode that typically occurs after…
Parkinson’s disease (PD) is the second common progressive neurodegenerative disorder next to Alzheimer’s disease. The pathological hallmark of Parkinson’s disease includes progressive loss of dopaminergic cells present in the substantia…
Voltage-gated NaV channels (NaVs) initiate action potentials in excitable cells and are crucial for electrical signaling from bacteria to man. Voltage-gated CaV channels (CaVs) are activated by depolarization during action…
mGluR (metabotropic glutamate receptor) is a type of glutamate receptor that are active through an indirect metabotropic process. They are members of thegroup C family of G-protein-coupled receptors, or GPCRs.…
Gamma-aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the vertebrate central nervous system. It is also a precursor of gamma‐hydroxybutyric acid (GHB). The GABA receptors are a class of…
PGAM5 (Phosphoglycerate Mutase Family Member 5) is a mitochondrial Ser/Thr phosphatase, usually located in the inner mitochondrial membrane (IMM). Specifically, it targets the phosphorylation of serine, threonine and histidine residues to exert dephosphorylation…
A number of evidence indicate that the serotonin (5-hydroxytryptamine, 5-HT) system participates in memory formation. Additionally, recent reviews provide further support to the notion that 5-HT1 to 5-HT4 and 5-HT6…