![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/01/TML-6-Inhibits-the-Synthesis-of-the-β-amyloid-Precursor-Proteina-nd-β-amyloid-2020-01-12.jpg)
Amyloid beta (Aβ) is a major component of amyloid plaques found in the brains of patients with Alzheimer’s disease. Specifically,…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/12/MS48107-is-a-Selective-GPR68-PAM-2020-12-26.jpg)
G protein-coupled receptor 68 (GPR68) is originally discovered as a clinically related receptor in an ovarian cancer cell line. GPR68…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/12/GR125743-is-a-Selective-5-HT1-B1D-Receptor-Antagonist-2020-12-15.jpg)
The negative feedback system regulates the 5-Hydroxytryptamine 5-HT release. Besides, the negative feedback system is mediated by autoreceptors located on…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/09/IOX4-is-a-Highly-Selective-PHD2-Inhibitor-2019-09-17.jpg)
Prolyl hydroxylases (PHDs) target hypoxia-inducible factor-1α (HIF-1α) for degradation. Hypoxia inactivates PHDs, causing accumulation of HIF-1α. In turn, HIF-1 further…