Glucokinase is a hexokinase isozyme that facilitates phosphorylation of glucose to glucose-6-phosphate. This is the rate-limiting step in glucose metabolism. Glucokinase occurs in cells in the liver and pancreas of…
The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) alleviate symptoms of experimental neuropathy, protect and stimulate the regeneration of sensory neurons in animal models of neuropathic pain, and…
Lp-PLA2 (Lipoprotein-associated phospholipase A2) is a calcium-independent serine lipase of 50-kDa that hydrolyzes the acetyl group at the sn-2 position of the platelet-activating factor. Importantly, Lp-PLA2 circulates in plasma bound…
Diabetes has a major impact on the global human population. Generally, blood glucose control is the major method of diabetes treatment. Previous studies indicated that targeting sodium glucose co-transporter-2 (SGLT-2)…
α2-adrenoceptor is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein. Besides, the α2-adrenoceptor not only inhibits the release of their neurotransmitters (autoreceptors) but can also regulate the…