The GLP receptors belong to a family comprising two members: the GLP-1 receptor (GLP1R, or GLP-1R) and the GLP-2 receptor (GLP2R, or GLP-1R), which can be activated by glucagon-like peptides…
PDE4B is an enzyme that in humans is encoded by the PDE4B gene. Importantly, PDE4B is involved in dopamine-associated and stress-related behaviors. Particularly, study show that reduction in PDE4B activity…
Dopamine Receptors belong the family of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). There are at least five subtypes of dopamine receptors, D1, D2,…
Epilepsy is one of the most common neurological diseases in the world. Firstly, Epilepsy affects people of all ages, races, social classes, and geographical locations. Secondly, Epilepsy is a disease…
Bacterial translation is the process by which messenger RNA is translated into proteins in bacteria. Importantly, the Inhibition of bacterial transcription and translation will inhibit bacterial growth and proliferation. In…
Striatal-enriched protein tyrosine phosphatase (STEP) is a CNS-rich protein associated with a variety of neurological and neuropsychiatric disorders. Firstly, it is expressed exclusively in the central nervous system. Then, it…
The N-methyl-D-aspartic acid (NMDA) receptor is the receptor of glutamic acid, which is the main excitatory neurotransmitter in the human brain. Specifically, NMDARs are related to the pathogenesis and development…
Sirtuin (Sir2 proteins) is a class of proteins. And it possesses either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in…
TLR4 is a transmembrane protein that belongs to the toll-like receptor family member of the pattern recognition receptor (PRR) family. Firstly, activation of Toll-like receptor 4 (TLR4) promotes the intracellular…
Stroke is the most serious and potentially deadly neurological disease and the most important factor leading to permanent disability in adults, significantly affecting the quality of life of stroke patients.…