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Omalizumab is an Antibody against human IgE for Persistent Allergic Asthma Research

Edward Jenner 2021-07-06

Immunoglobulin E (IgE) is an immunoglobulin, which plays a central role in acute allergic reactions and chronic inflammatory allergic diseases. Specifically, it is one of the five immunoglobulins (A, G,…

Asthma Bronchial Airway Infection Inflammation Respiratory Infection

Lodoxamide, an Antiallergic Compound, Acts as a Mast-Cell Stabilizer

Edward Jenner 2021-06-18

Mast cell stabilizers prevent or control certain allergic disorders. In particular, Lodoxamide is a mast cell stabilizer. Furthermore, Lodoxamide inhibits mast cell degranulation in vitro and in vivo. Lodoxamide is…

Asthma Atopic Dermatitis Bronchial Airway Infection

AS1810722 is an Orally Active STAT6 Inhibitor

Edward Jenner 2021-05-13

Signal transducers and activators of transcription 6 (STAT6) is an important transcription factor in IL-4 signaling pathway. STAT6 is also a key regulator of the Th2 cell immune response. Therefore,…

Asthma Chronic Obstructive Pulmonary Disease

CHF5407 is a Muscarinic M3-Receptor Antagonist

Edward Jenner 2021-04-29

Muscarinic M3 receptors are a subtype of Muscarinic acetylcholine receptors (mAChRs). Specifically, mAChRs is acetylcholine receptor, which forms a G-protein-coupled receptor complex in the cell membrane of some neurons and…

Asthma Inflammation Respiratory Infection

PNRI-299 is a Selective AP-1 Transcription Inhibitor

Edward Jenner 2021-04-28

Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli. Specifically, AP-1 controls many cellular processes, including differentiation, proliferation, and apoptosis.…

Asthma Bronchial Airway Infection Inflammation Respiratory Infection

TEI-9648 is a Specific Vitamin D Receptor (VDR) Antagonist

Edward Jenner 2021-04-06

Vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. Calcitriol (the active form of vitamin D, 1,25-(OH)2 vitamin D3) binds to VDR and then…

Asthma Bronchial Airway Infection Cancer Immunology Inflammation

GS143 is a Selec­tive IκBα Ubiquitination Inhibitor

Edward Jenner 2020-09-01

GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. Firstly, when GS143 treatment at different doses in THP-1 cells. GS143 suppresses the…

Asthma Chronic Obstructive Pulmonary Disease

PF-610355 is a Long-Acting Inhaled β2-Adrenoreceptor Agonist

Edward Jenner 2020-05-23

β2-adrenoreceptor is a kind of β-adrenergic receptor across the cell membrane, which binds to adrenaline. Specifically, Adrenaline is a kind of hormone and neurotransmitter and it can enhance the signal…

Allergy Asthma Fibrosis Kidney Fibrosis Rhinitis

CAY10471 is a Selective and Orally Active CRTH2 Antagonist

Edward Jenner 2020-05-07

CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. In PC12 cells, CAY10471 blocks 15d-PGJ2-induced p38 MAP kinase activation and decreases phosphorylation of p-38 MAP…

Asthma

Valategrast is an Orally Active Integrin α4β1 and α4β7 Antagonist

Edward Jenner 2020-04-08

Asthma is an inflammatory disorder of the airways. Moreover, asthma is a long-term disease of the lungs. The features of asthma pathophysiology are the production of cytokines and infiltration of…

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You Missed

Pulmonary Arterial Hypertension (PAH)

PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH

Cancer Immune Metabolic Disease

Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research

Uncategorized

Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research

NASH obesity

Elafibranor is a PPARα/δ Agonist for Metabolic Disease Research

Immune System Research

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