Immunoglobulin E (IgE) is an immunoglobulin, which plays a central role in acute allergic reactions and chronic inflammatory allergic diseases. Specifically, it is one of the five immunoglobulins (A, G,…
Mast cell stabilizers prevent or control certain allergic disorders. In particular, Lodoxamide is a mast cell stabilizer. Furthermore, Lodoxamide inhibits mast cell degranulation in vitro and in vivo. Lodoxamide is…
Signal transducers and activators of transcription 6 (STAT6) is an important transcription factor in IL-4 signaling pathway. STAT6 is also a key regulator of the Th2 cell immune response. Therefore,…
Muscarinic M3 receptors are a subtype of Muscarinic acetylcholine receptors (mAChRs). Specifically, mAChRs is acetylcholine receptor, which forms a G-protein-coupled receptor complex in the cell membrane of some neurons and…
Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli. Specifically, AP-1 controls many cellular processes, including differentiation, proliferation, and apoptosis.…
Vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. Calcitriol (the active form of vitamin D, 1,25-(OH)2 vitamin D3) binds to VDR and then…
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. Firstly, when GS143 treatment at different doses in THP-1 cells. GS143 suppresses the…
β2-adrenoreceptor is a kind of β-adrenergic receptor across the cell membrane, which binds to adrenaline. Specifically, Adrenaline is a kind of hormone and neurotransmitter and it can enhance the signal…
CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. In PC12 cells, CAY10471 blocks 15d-PGJ2-induced p38 MAP kinase activation and decreases phosphorylation of p-38 MAP…
Asthma is an inflammatory disorder of the airways. Moreover, asthma is a long-term disease of the lungs. The features of asthma pathophysiology are the production of cytokines and infiltration of…