GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. Firstly, when GS143…
β2-adrenoreceptor is a kind of β-adrenergic receptor across the cell membrane, which binds to adrenaline. Specifically, Adrenaline is a kind…
CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. In PC12 cells, CAY10471 blocks 15d-PGJ2-induced…
Asthma is an inflammatory disorder of the airways. Moreover, asthma is a long-term disease of the lungs. The features of…
The arachidonic acid cascade forms a plethora of proinflammatory and pro-resolution lipid metabolites, including prostaglandins, thromboxanes, and leukotrienes. In particular,…