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Category: Encephalomyelitis

BAY-1316957 is a Selective and Orally Active EP4-R Antagonist

2021-03-24 Edward Jenner

Prostaglandin E2 (PGE2) receptors (EP4-R) are a particularly promising anti-inflammatory and antinociceptive target. Prostaglandin E2 (PGE2) is responsible for inflammatory…

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Posted in: Encephalomyelitis, Inflammation Filed under: EP4-R, UGT1A

BIO-1211 is a Highly Selective and Orally Active α4β1 (VLA-4) Inhibitor

2020-08-27 Edward Jenner

Very Late Antigen-4 (VLA4 or CD49d/CD29) is aα4β1 integrin with a pivotal role in controlling immune cell migration into inflamed…

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Posted in: Autoimmune Disorders, Encephalomyelitis, Inflammation Filed under: EAE, Encephalomyelitis, IFN-γ, IL-17, Integrin, TNF-α, VLA-4, α4β1
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