PPAR, or peroxisome proliferator-activated receptor, involves in the regulation of glucose homeostasis, lipid metabolism, and vascular inflammation. PPAR-α, also known as NR1C1, is a nuclear receptor protein. It is the…
The GLP receptors belong to a family comprising two members: the GLP-1 receptor (GLP1R, or GLP-1R) and the GLP-2 receptor (GLP2R, or GLP-1R), which can be activated by glucagon-like peptides…
Fatty acid synthase (FASN) is a central regulator of lipid metabolism. FASN provides the fatty acids needed to sustain tumor growth, as a potential target for human malignant tumors. And…
Glucagon plays an important role in glucose metabolism. Upon hypoglycemia, pancreatic alpha cells can secrete glucagon which stimulates hepatic glucose production. However increased glucagon concentrations contribute to diabetic hyperglycemia. In…
Glucagon receptor (GCGR), a 62 kDa protein, is a member of the class B G-protein coupled family of receptors. GCGR mainly exists in the liver and in the kidney. In…
Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino acid peptide hormone produced and secreted by intestinal enteroendocrine L-cells and certain neurons within the nucleus of the solitary tract in the brainstem upon food consumption. GLP-1 can…
Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme. Specifically, NNMT is involved in controlling methylation potential and influencing epigenetic modification of DNA and histones. Specifically, it uses the universal methyl donor…