mGluR (metabotropic glutamate receptor) is a type of glutamate receptor that are active through an indirect metabotropic process. They are members of thegroup C family of G-protein-coupled receptors, or GPCRs.…
PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 µM; Ki=5.9 nM). PLX5622 allows for extended and specific microglial cell elimination, preceding and during pathology development. Additionally, PLX5622 demonstrates…
Dopamine Receptors belong the family of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). There are at least five subtypes of dopamine receptors, D1, D2,…
Striatal-enriched protein tyrosine phosphatase (STEP) is a CNS-rich protein associated with a variety of neurological and neuropsychiatric disorders. Firstly, it is expressed exclusively in the central nervous system. Then, it…
Nuclear factor kappa B (NF-κB) family transcription factors are the master regulators. NF-κB is indispensable for a wide variety of biological processes including inflammation and the immune system. NF-kB functions…
Double leucine zipper kinase (DLK, MAP3K12) and leucine zipper Carrying kinase (LZK, MAP3K13) are two homologous mitogen-activated protein kinases. They are regulators of neuronal apoptosis and axon degradation. And also…
The endogenous cannabinoid system consists of endogenous cannabinoids, cannabinoid receptors, and enzymes that synthesize and degrade endogenous cannabinoids. Specifically, many effects of cannabinoids and endogenous cannabinoids are mediated by two…
Histamine receptors are a type of G protein-coupled receptor (GPCR), including four subtypes: H1, H2, H3, and H4 receptors. They have different functions. For example, the H1 receptor regulates circadian…
Leucine Rich Repeat Kinase 2 (LRRK2) is a member of the leucine-rich repeat kinase family. Researchers found that the mutations in LRRK2 account for approximately 3-4% of Parkinson's disease patients.…
Microglia is a kind of resident immune cell in the central nervous system (CNS) parenchyma. microglia remain in a quiescent state Under normal physiological conditions. Besides, Brain injury and some…