Signal peptide peptidase-like 2a (SPPL2a) is a member of the signal peptide peptidase like protease (SPPL) family. Specifically, SPPL2a encodes lysosome/late endosomal membrane protein and has conserved active-site motifs "YD"…
Major depressive disorder (MDD) is a chronic illness. And it affects ~17% of the population and one leading cause of disability in the world. Currently, drugs that influence monoamine neurotransmission…
CPT-11 and Topotecan are two potent DNA topoisomerase I inhibitors in clinical. CPT-11 is the prodrug of SN-38. Topotecan is a water-soluble semisynthetic derivative of Camptothecin. CPT-11 is mainly for…
Guanylyl cyclase-C (GC-C) is a transmembrane receptor for bacterial heat-stable enterotoxin and the mammalian peptides guanylin and uroguanylin. Guanylyl cyclase-C mediates intestinal ion secretion and affects intestinal cell growth via…
Gamma secretase (γ-Secretase) is a kind of multi-subunit protease complex, which is an indispensable membrane protein. Specifically, γ-Secretase cleaves one-way transmembrane proteins at residues in the transmembrane domain. Besides, the…
Neuropilin-1 (NRP1) is a membrane-bound co-receptor of the tyrosine kinase receptor, which can be used for vascular endothelial growth factor and signal protein family members. Specifically, NRP1 plays a variety…
STING is a protein with four putative transmembrane domains and resides in the endoplasmic reticulum. STING widely expresses in both immune cells (including innate immune cells and adaptive immune cells)…
Histone deacetylases (HDACs) and RNA polymerase III (POLR3) play vital roles in fundamental cellular processes. In particular, POLR3 mediates transcription of non-coding RNAs. ML-60218 is a potent and selective inhibitor…
Innate immunity is the first-line cellular stress response. Additionally, it is a good way for defending the host cell against invading pathogens. These processes involve pathogen-associated molecular patterns (PAMPs) through…