![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/11/SEW2871-is-a-Highly-Selective-and-Orally-Active-S1P1-Agonist-2019-11-07.jpg)
G protein-coupled receptors (GPCRs) are also known as 7TM receptors due to their transmembrane domains. they constitute the largest superfamily…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/09/C-178-is-a-Covalent-Small-Molecule-Inhibitor-of-STING-2019-09-26.jpg)
In the previous blog, I have introduced C-176 as a strong and covalent mouse STING inhibitor. Today, I’d like to…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/07/MRT67307-is-a-Dual-Inhibitor-of-the-IKKε-and-TBK-1-2019-07-02.jpg)
IKK {IκB [inhibitor of NF-κB (nuclear factor κB)] kinase} family plays a indispensable role in innate immunity by inducing NF-κB-…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/05/PF-06928215-a-High-Affinity-Inhibitor-of-cGAS-2019-05-30.jpg)
Interferons (IFNs) are a group of signaling proteins in response to the presence of several viruses. Cyclic GMP-AMP Synthase (cGAS,…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/05/BRD5631-Enhances-Autophagy-through-mTOR-Independent-Pathway-2019-05-14.jpg)
Scientists have demonstrated the regulation of autophagy in inflammation, neurodegeneration, infection, and autoimmunity. And the findings motivate the use of…