Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs) that play an important role in the host's innate immune response and immunity homeostasis. Additionally, Members of the…
Stimulator of interferon genes (STING), an integral ER-membrane protein, is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. It…
Calcium-activated chloride channels (CaCCs) are always expressed in epithelial and nonepithelial cells. They are involved in epithelial fluid secretion, sensory signal transduction, smooth muscle contraction, oocyte fertilization, and other functions.…
G protein-coupled receptors (GPCRs) are also known as 7TM receptors due to their transmembrane domains. they constitute the largest superfamily of receptors for signaling molecules, ligands Many ligands, including hormones,…
In the previous blog, I have introduced C-176 as a strong and covalent mouse STING inhibitor. Today, I’d like to introduce another STINF inhibitor C-178 in the same article. STING,…
IKK {IκB kinase} family plays a indispensable role in innate immunity by inducing NF-κB- and IRF -dependent gene transcription programmes required for the production of pro-inflammatory cytokines and IFNs. A…
Interferons (IFNs) are a group of signaling proteins in response to the presence of several viruses. Cyclic GMP-AMP Synthase (cGAS, cGAMP synthase) is a cytosolic DNA sensor. Especially, cGAS activates…
Scientists have demonstrated the regulation of autophagy in inflammation, neurodegeneration, infection, and autoimmunity. And the findings motivate the use of small-molecule probes to study the effects of autophagy on disease-associated…
Bromodomain-containing protein 4 belongs to the family of bromodomain and extra-terminal domain (BET) proteins. The BET family is considered as the most druggable target proteins among Bromodomain-containing proteins (BCPs) for…
Tyrian purple is a natural dye produced by gastropod mollusks. It consists of mixed bromine-substituted indigo and indirubin isomers. Among them, there are natural products and their derivatives. They possess…