iKIX1 is an anti-fungal agent and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro. In HepG2 cells, iKIX1 inhibits cell growth in a concentration-dependent manner in the presence of…
Onychomycosis is an infection of the nail plate that is prevalent among the ageing population. Onychomycosis is difficult to treat with low initial cure rates, high rates of relapse, and…
Exosomes act as vesicles of endosomal origin secreted from reticulocytes. Exosomes bear proteins, lipids, and RNAs, mediating intercellular communication between different cell types in the body, and thus affecting normal…
The mevalonate pathway consists of a series of enzymes in mammalian cells. Those enzymes can transform acetyl-Coenzyme-A (CoA) to cholesterol ubiquinone, and dolichol via mevalonate. It has been proved that…
Invasive pulmonary aspergillosis (IPA) is the leading cause of mold infections in the immunocompromised host. Despite the current aggressive antifungal therapy, IPA still results in a high percentage of fatalities…