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Category: Fungal

Hypothemycin, a Fungal Polyketide, is a Multikinase Inhibitor

2022-01-13 Edward Jenner

The kinase is an enzyme. And it catalyzes the transfer of a phosphate group from a high-energy donor molecule to…

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Posted in: Fungal, Infection Filed under: COLO829, ERK1, ERK2, FLT3, Leukemia, MEK1, MEK2, Melanoma, PDGFRα, PDGFRβ, VEGFR1, VEGFR2

Oteseconazole is an Orally Active Anti-Fungal Agent

2021-11-30 Edward Jenner

Fungal infections are a common occurrence, with an estimated worldwide prevalence of 20% to 25%. Consistent with most of Europe…

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Posted in: Fungal Filed under: CYP51, Onychomycosis

Oligomycin A (MCH 32) Acts as a Mitochondrial F0F1-ATPase Inhibitor

2021-10-13 Edward Jenner

F-ATPase exists in the bacterial plasma membrane, mitochondrial inner membrane, and chloroplast thylakoid membrane. Specifically, it uses proton gradients to…

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Posted in: Fungal Filed under: F0F1-ATPase, NCI-60

iKIX1 Inhibits the Interaction of the CgGal11A KIX Domain and the CgPdr1 Activation Domain

2020-11-10 Edward Jenner

iKIX1 is an anti-fungal agent and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro. In HepG2 cells, iKIX1 inhibits…

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Posted in: Fungal Filed under: Antifungal, CgGal11A, CgPdr1, Infection

ME1111, an Antifungal Agent and Succinate Dehydrogenase Inhibitor, has the Potential to Treat Onychomycosis

2020-04-25 Edward Jenner

Onychomycosis is an infection of the nail plate that is prevalent among the ageing population. Onychomycosis is difficult to treat…

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Posted in: Fungal Filed under: Antifungal, Onychomycosis, Succinate Dehydrogenase

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