Oteseconazole is an Orally Active Anti-Fungal Agent
Fungal infections are a common occurrence, with an estimated worldwide prevalence of 20% to 25%. Consistent with most of Europe and the United States, a recent retrospective study found that…
Fungal infections are a common occurrence, with an estimated worldwide prevalence of 20% to 25%. Consistent with most of Europe and the United States, a recent retrospective study found that…
A protein phosphatase is a phosphatase enzyme that removes a phosphate group from the phosphorylated amino acid residue of its substrate protein. Protein phosphatases (PPs) are the primary effectors of…
Hydrogen sulfide (H2S), a recognized environmental pollutant, comes from a wide range of sources. For example, H2S will be produced in the process of plant protein corruption, the decomposition of…
Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase. Specifically, the enzyme is a key regulator of many signaling pathways. It includes cellular responses to Wnt, receptor tyrosine kinase,…
Some Gram-negative pathogens have accumulated enough resistance mechanisms to render them virtually untreatable by modern antibacterial chemotherapy. A mainstay for the treatment of Gram-negative infections is the β-lactam classes of…
Farnesyl Transferase (FTase) is a heterodimeric enzyme containing α and β subunit in mammalian cells. FTase is one of the three enzymes in the prenyltransferase group. The activity of FTase…
PKC (Protein kinase C) is a family of protein kinase enzymes. In mammals, the PKC family members has four structurally and functionally distinct subgroups according to their regulatory domains. These…
Dynamins are large superfamily GTPase proteins that are involved in various cellular processes including budding of transport vesicles, division of organelles, cytokinesis, and pathogen resistance. Dynamins contain five domains, including…
HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the…
Sigma receptors are orphan receptors. There are two subtypes of sigma receptors, sigma-1 and sigma-2. Although sigma-1 receptors promote cell growth and thus inhibit cell death, activation of sigma-2 receptors…