Chronic kidney disease (CKD) affects approximately 10% of the adult population in developed countries. Renal fibrosis plays a pivotal role in the development and progression of CKD as well as…
CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. In PC12 cells, CAY10471 blocks 15d-PGJ2-induced p38 MAP kinase activation and decreases phosphorylation of p-38 MAP…
NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase; Nox) is a membrane-bound enzyme complex, which faces extracellular space. It catalyzes the production of superoxide free radical through transferring an electron from…
Integrins are cell surface protein receptors with α and β subunits. They participate in multiple cellular functions such as adhesion and anchoring to extracellular matrix, transducing growth factor signals. Emerging…