Ramelteon is a potent, highly selective, and orally active agonist of MT1/MT2. Strikingly, it has the potential for the research of insomnia. And Ramelteon consistently reduces sleep onset after long-term…
Spleen tyrosine kinase (Syk) is a 72 kDa non-receptor tyrosine kinase. Specifically, Syk is activated by binding the tandem SH2 domain to the immune receptor tyrosine activation motif (ITAM). Syk…
DNA topoisomerases are enzymes that disentangle the topological problems that arise in double-stranded DNA by the generation of either single or double strand breaks. Topoisomerases are ubiquitous enzymes, exsist in…
The transcriptional coactivator with a PDZ-binding motif (TAZ, also called WWTR1) acts as an N-terminal TEAD-binding domain, one or two WW domains, and a transcriptional activation domain. The Hippo pathway…
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Meanwhile,…
PK 11195, a ligand of this protein, acts as an anti-leishmanial agent. At the same time, PK 11195 exhibits IC<sub>50</sub> values of 14.2 μM for L. amazonensis, 8.2 μM for…
Fasiglifam (TAK-875) acts as a novel, orally available, selective GPR40 agonist. TAK-875 (0.01-10 μM) produces a concentration-dependent increase in intracellular IP production in CHO-hGPR40, with EC50 of 0.072 μM. Fasiglifam…
Fatty acid synthase (FASN) is a key metabolic enzyme. It has relations with catalyzing the terminal steps in long chain saturated fatty acid synthesis. In most human tissues, FASN has…