Sigma Ligands has cytotoxic activity in vitro and is able to induce ceramide/caspase-independent apoptosis. In addition, these ligands down-regulate P-glycoprotein (P-gp) mRNA levels in some mouse and human models. In…
The protein-protein interaction between menin and MLL fusion proteins plays a critical role in the pathogenesis of MLL leukemia. The genetic disruption of this interaction abrogates the development of acute…
Aminoacyl-tRNA synthetases (ARSs) is an important enzyme and conjugates amino acids to their cognate tRNAs during protein synthesis. In higher eukaryotic systems, ARS-interacting multifunctional proteins (AIMPs) and ARSs form a…
Persistent or reactivated signaling by the androgen receptor drives the progression of prostate cancer to a deadly form of the disease, namely metastatic castration-resistant prostate cancer (mCRPC). The RAR-related orphan…
Mammalian cell division involves an orderly progression through four distinct phases: G1 (growth phase 1), S (DNA synthesis), G2 (growth phase 2), and M (mitosis). During the G1 phase, cells…