Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant myeloid cell infiltrates. The immunosuppression, fibrosis, T cell dysfunction, and poor prognosis in patients with PDAC associate with these infiltrates. The cells…
The Hedgehog (Hh) protein family includes Sonic (Shh), Indian (Ihh), and Desert (Dhh) hedgehogs, which regulates numerous events in embryonic development. Patched-1 is a receptor for all of the hedgehog…
Oncogenic c-Ros oncogene1 (ROS1) fusion kinases have been identified in a variety of human cancers and are attractive targets for cancer therapy. The MET/ALK/ROS1 inhibitor has demonstrated promising clinical activity…
Recruitment of myeloid-derived suppressor cells (MDSCs) into tumors induces local immunosuppression in carcinomas. CXCR2+ neutrophilic MDSCs (PMN-MDSCs) are the most abundant myeloid cell subset within oral and lung syngeneic carcinomas….
As we all know, Farnesyl diphosphate synthase(FPPS) is an important drug target for bone resorption, cancer, and some infectious diseases. Besides, FPPS and undecaprenyl diphosphate synthase (UPPS) involves in bacterial…