Recruitment of myeloid-derived suppressor cells (MDSCs) into tumors induces local immunosuppression in carcinomas. CXCR2+ neutrophilic MDSCs (PMN-MDSCs) are the most abundant myeloid cell subset within oral and lung syngeneic carcinomas….
As we all know, Farnesyl diphosphate synthase(FPPS) is an important drug target for bone resorption, cancer, and some infectious diseases. Besides, FPPS and undecaprenyl diphosphate synthase (UPPS) involves in bacterial…
Prolyl hydroxylases (PHDs) target hypoxia-inducible factor-1α (HIF-1α) for degradation. Hypoxia inactivates PHDs, causing accumulation of HIF-1α. In turn, HIF-1 further transactivates PHDs. Asparaginyl hydroxylation also regulates HIFα. Asparaginyl hydroxylation is…
As previously introduced, we all have known that RRx-001, a hypoxia-selective epigenetic agent and a radio- and chem-sensitizer. Additionally, it triggers apoptosis and overcomes drug resistance in myeloma. RRx-001 exhibits…
Necroptosis is a form of regulated necrosis controlled by receptor-interacting kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL). Necroptosis closely associates with pathologies including inflammatory diseases, neurodegenerative…