Histone deacetylases (HDACs) and RNA polymerase III (POLR3) play vital roles in fundamental cellular processes. In particular, POLR3 mediates transcription of non-coding RNAs. ML-60218 is a potent and selective inhibitor…
Camptothecin is isolated from the bark of Camptotheca acuminita (a traditional Chinese medicine used for cancer treatment). Especially, Camptothecin is a topoisomerase I inhibitor. Furthermore, Camptothecin binds to the enzyme…
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. Firstly, when GS143 treatment at different doses in THP-1 cells. GS143 suppresses the…
CXC chemokine receptors are the complete membrane proteins and they can specifically bind and respond to CXC chemokine family cytokines. Specifically, they represent a subfamily of chemokine receptors, a large…
Leukotriene B4 (LTB4) is a lipid mediator with potent chemoattractant properties. Activated innate immune cells such as neutrophils, macrophages, and mast cells rapidly generate LTB4. Ligation of BLT1 by LTB4…