Hsp90 is a molecular chaperone, it is essential for the conformational stability and activity of many key oncogenic proteins. These proteins include not only kinases such as ErbB2, B-Raf, Alk,…
In previous blogs, we have introduced a lot of PROTAC based degraders, including TD-428, HJB97, A1874, etc. Coincidentally most of them are all PROTAC-based BET degraders. Today, I’d like to…
Fascin 1 (fascin) is an actin-bundling protein. It cross-links filamentous actin (F-actin) into tightly packed parallel bundles driving the formation of various cell surface protrusions, such as filopodia and invadopodia….
PI3Ks are key drivers of the survival and growth of normal B cells. PI3K catalyzes the phosphorylation of PI(4,5)P2 to generate PI(3,4,5)P3. It serves as a docking site at the…
Protein lysine methyltransferases (PKMTs, HMTs) are an important target class for modulation to regulate gene expression, cell differentiation, and organismal development. Polycomb repressive complex 2 (PRC2) that catalyzes methylation of…