Phospholipase C (PLC) family members constitute a family of diverse enzymes. The PLC family members contain two highly related structural domains with conserved amino acid sequences. Phospholipase C-γ (PLC-γ) acts…
Acute myeloid leukemia (AML) is a fatal form of hematopoietic malignancies. current treatment for AML involves multiple cycles of high-dose cytarabine (Ara-C) treatment, this kind of treatment impairs the quality…
Multiple myelomas (MM) is a plasma cell malignancy that accounts for approximately 10% of all hematological malignancies. Many new drugs and therapies apply to this disease, but it remains an…
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant myeloid cell infiltrates. The immunosuppression, fibrosis, T cell dysfunction, and poor prognosis in patients with PDAC associate with these infiltrates. The cells…
The Hedgehog (Hh) protein family includes Sonic (Shh), Indian (Ihh), and Desert (Dhh) hedgehogs, which regulates numerous events in embryonic development. Patched-1 is a receptor for all of the hedgehog…