Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease, affecting many people in the industrialized world. Synoviolin (Syvn1) is highly expressed in synoviocytes of patients with RA. Overexpression…
The CC-type chemokine receptor 1 (CCR1) is a chemokine receptor of significant importance in human health. CCR1 is a protein that in humans is encoded by the CCR1 gene. Moreover,…
Cyclooxygenase (COX) -2 is an inducible form of COX, and it involves in inflammation. In addition, Malignant mesothelioma (MM) is a fatal malignancy with an estimated incidence of 3,000 cases…
Biologic agents are highly effective therapies. It greatly improves the standard of care for patients with rheumatoid arthritis (RA). Even with the significant improvement in care, the maximal benefit has…
The TRAF protein family comprises seven E3 ligase members, including TRAF6. Distinct receptor signaling pathways have different members, such as the IL-1 receptor family, T-cell receptor (TCR), IL-17 receptor, TNF…