Janus kinases (JAKs) are cytoplasmic tyrosine kinases. JAKs link cytokine signaling from membrane receptors to signal transducer and activator of…
Leukocyte function-associated antigen-1 (LFA-1), also known as CD11a/CD18 and αLβ2, is a member of the β2-integrin family found on lymphocytes…
Inhibition of monocyte and macrophage function by targeting chemokine receptors represents an attractive strategy for therapeutic intervention in inflammatory diseases.…
Bone is a complex tissue that contains various types of cells. There exist two major cell types responsible for bone…
Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease, affecting many people in the industrialized world. Synoviolin (Syvn1)…