The TRAF protein family comprises seven E3 ligase members, including TRAF6. Distinct receptor signaling pathways have different members, such as the IL-1 receptor family, T-cell receptor (TCR), IL-17 receptor, TNF…
Bruton’s tyrosine kinase (BTK), a member of the Tec family of tyrosine kinases, is expressed in B cells, macrophages, and monocytes, but not in T cells. Mutations in the human…
In previous blogs, we have introduced a few MAPK p38 inhibitors. As a result, MAPK p38 plays an important role in many diseases, including cancer and inflammatory diseases. Today, I’d…
IκB kinase 2 (IKK-2) plays a pivotal role in the nuclear factor-κB-regulated production of proinflammatory molecules by stimuli, such as tumor necrosis factor (TNF)-αand interleukin (IL)-1. Thus, inhibition of IKK-2…
CH-223191 inhibits smoking-induced aggravation of experimental arthritis via aryl hydrocarbon receptor (AHR). Firstly, as we all know, smoking has become a major risk factor of people’s health. It involves in…