Chronic hypoxia leads to pulmonary hypertension and pulmonary vascular remodelling in many mammalian species. Hypoxic pulmonary vasoconstriction (HPV) is thought to play a key role in the development of pulmonary…
Type I interferons are important innate and adaptive immune response factors. It derivates from infected cells and in turn, induces the cells to create an antimicrobial environment that limits the…
Hepatitis B, a liver disease, is the one of most widespread infectious diseases in the world. There are 1.5 million people who become newly infected patients every year. It can…
COVID-19 is an infectious disease caused by the coronavirus (SARS-CoV-2), which mainly causes symptoms such as fever and cough. It spreads through droplet transmission or contact transmission. Since 2019, COVID-19…
TGF-β1 is a cytokine transforming growth factor β Polypeptide member of the superfamily. Specifically, it is a secretory protein with a variety of cellular functions, including the control of cell…
Hepatitis C virus (HCV) is a member of the Flaviviridae family of viruses in the Hepacivirus genus. Meanwhile, HCV NS3-4A serine protease is a complex composed of NS3 and its…
The character of nonalcoholic fatty liver disease (NAFLD) is the accumulation of fat (in excess of 5%) within the hepatocytes. The molecular etiology of NASH is complex, including disordered metabolism,…
The therapeutic potential of extra terminal domain inhibitor (iBET) has increasing studies both in oncology and immunoinflammatory. Moreover, iBETs are actively progressing in the clinic for oncology indications. Nevertheless, there…
In our previous blogs, we have introduced two HBV inhibitors. Today, I’d like to describe another small molecule compound BA-53038B that targets HBV core protein. A study from Xuexiang Zhang…