Etrasimod is a potent, selective, and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor. And the IC50 value is 1.88 nM in CHO cells. Firstly, in vitro, In CHO cells expressing HA-tagged…
The symptoms of Allergic rhinitis are rhinorrhea, sneezing, nasal pruritus, congestion, and aggravation of comorbid asthma. Histamine can interact with 4 receptor subtypes, including H1, H2, H3, and H4. Many…
CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. In PC12 cells, CAY10471 blocks 15d-PGJ2-induced p38 MAP kinase activation and decreases phosphorylation of p-38 MAP…