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Category: Complement System

PMX-53 is an Orally Active Complement C5a Receptor Antagonist

2020-06-09 Edward Jenner

C5a is an important inflammatory hypernociceptive mediator, acting by a mechanism independent of hypernociceptive cytokine release, but dependent on the…

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Posted in: Allergy, Complement System, Inflammation Filed under: Anti-Tumor, Antiatherosclerotic, C5a, CD88

MK-0429 is An Oral Integrin (αvβ3) Inhibitor

2019-04-11 Edward Jenner

Integrins are cell surface protein receptors with α and β subunits. They participate in multiple cellular functions such as adhesion…

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Posted in: Cancer Immunology, Complement System, Kidney Fibrosis Filed under: Integrin
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5-HT Anti-Inflammatory Anti-Tumor Antibacterial Antibiotic Antimalarial Antitumor Antiviral Apoptosis Autophagy Breast Cancer Chemokines COPD COVID-19 Cytokine Dopamine EGFR HBV HCV HDAC HIV IFN IL-6 Infection Inflammasome Integrin Interferon Interleukin IPF JAK Leukemia Low Toxicity Multidrug Resistance NF-κB p38 MAPK PI3K Proteasome RIPK ROS STING T Cell Th17 TLR TNF TNF-α
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