Dopamine D1 receptors are important G protein-coupled receptors in the central nervous system (CNS). They activate different effectors through G protein coupling and interact with the neurotransmitter dopamine to signal.…
The sigma-1 receptor (σ1R， S1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. Moreover, the…
Glycine transporters (GlyTs) are the Na+/Cl--dependent plasmalemmal neurotransmitter transporters. GlyTs comprise GlyT1 and GlyT2. They serve to terminate the signaling of glycine by mediating its reuptake from the synaptic cleft…
Oxytocin Receptor, also known as OXTR, OTR, is the receptor protein for oxytocin and is encoded by the OTR gene located on human chromosome 3p25. OTR protein belongs to the…
Histamine receptors are a type of G protein-coupled receptor (GPCR), including four subtypes: H1, H2, H3, and H4 receptors. They have different functions. For example, the H1 receptor regulates circadian…
Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. GlyTs, which regulate brain glycine levels, is an inhibitory neurotransmitter with co-agonist activity for NMDA receptors (NMDARs). Meanwhile, GlyTs comprise glycine transporter type 1 (SLC6A9;…
Antipsychotics are a class of medication for managing psychosis, principally in schizophreniabut also in a range of other psychotic disorders. First-generation antipsychotics are dopamine receptor antagonists and are known as…